Evidence map›Paper›PMID 31703562›Full record

ArticleBMC infectious diseases2019

Glutathione, glutathione peroxidase and some hematological parameters of HIV-seropositive subjects attending clinic in University of Calabar teaching hospital, Calabar, Nigeria.

Stephen Bassey Coco-Bassey, Enosakhare A Asemota, Henshaw Uchechi Okoroiwu, Joyce E Etura, Esienanwan Esien Efiong, Imeobong J Inyang, Emmanuel K Uko

Open access · goldAbstract read
In one paragraph

Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Glutathione in HIV-Associated Neurocognitive Disorders.Current issues in molecular biology · 2024
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Stephen Bassey Coco-BasseyHaematology Unit, University of Calabar Teaching Hospital, Calabar, Nigeria.
Enosakhare A AsemotaHaematology Unit, Department of Medical Laboratory Science, University of Calabar, Calabar, Nigeria.
Henshaw Uchechi OkoroiwuHaematology Unit, Department of Medical Laboratory Science, University of Calabar, Calabar, Nigeria. okoroiwuhenshaw@gmail.com.ORCID http://orcid.org/0000-0003-2658-3788
Joyce E EturaHaematology Unit, Department of Medical Laboratory Science, University of Calabar, Calabar, Nigeria.
Esienanwan Esien EfiongDepartment of Biochemistry, Federal University of Lafia, Nasarawa, Nigeria.
Imeobong J InyangHaematology Unit, Department of Medical Laboratory Science, University of Calabar, Calabar, Nigeria.
Emmanuel K UkoHaematology Unit, Department of Medical Laboratory Science, University of Calabar, Calabar, Nigeria.
University of Calabar · NGFederal University Lafia · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite the numerous intervention programmes, HIV still remains a public health concern with a high impact in Sub-Saharan Africa region. Oxidative stress has been documented in HIV subjects as viral infection promotes prolonged activation of immune system, hence, production of increased reactive oxygen species.

methodsWe studied 180 subjects. Of these, 60 were HIV-infected on antiretroviral therapy (ART), 40 were ART naïve HIV-infected and 80 were apparent healthy non HIV-infected subjects. The complete blood count was performed by automated hemoanalyzer, the CD4

resultAll evaluated parameters; glutathione (GSH), glutathione peroxidase (GPX), CD4

conclusionAntioxidants; GSH and GPX were found to be significantly reduced in HIV infection. Further probe showed that the antioxidant status was improved in the HIV-infected group on ART.

Indexed as

HIV SeropositivityAdultAnemiaAnti-Retroviral AgentsCD4 Lymphocyte CountFemaleGlutathioneGlutathione PeroxidaseHIV InfectionsHospitals, UniversityHumansMaleNigeriaOxidative StressPlatelet CountPrevalenceAnti-Retroviral AgentsGlutathioneGlutathione PeroxidaseAntioxidantsCalabarGlutathioneGlutathione peroxidaseHIV

Identifiers

PMID31703562
PMCPMC6842150
OpenAlexW2986733419

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.