Evidence map›Paper›PMID 31703545›Full record

ArticleJournal of immunotoxicology2019

Exposure to low-dose arsenic in early life alters innate immune function in children.

Faruque Parvez, Evana Akhtar, Lamia Khan, Md Ahsanul Haq, Tariqul Islam, Dilruba Ahmed, Hem Mahbubul Eunus, Akm Rabiul Hasan, Habibul Ahsan, Joseph H Graziano and 1 more

Open access · goldAbstract readVideo-Audio Media
In one paragraph

Article in Journal of immunotoxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2020
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Maternal Folate Status and the Relation between Gestational Arsenic Exposure and Child Health Outcomes.International journal of environmental research and public health · 2022
    Article
  6. Review
  7. Article
  8. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Faruque ParvezDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
Evana AkhtarInfectious Diseases Division, icddr,b, Dhaka, Bangladesh.
Lamia KhanInfectious Diseases Division, icddr,b, Dhaka, Bangladesh.
Md Ahsanul HaqInfectious Diseases Division, icddr,b, Dhaka, Bangladesh.
Tariqul IslamColumbia University and University of Chicago Research office in Bangladesh, Dhaka, Bangladesh.
Dilruba AhmedLaboratory Sciences and Services Division, ICDDR,B, Dhaka, Bangladesh.
Hem Mahbubul EunusColumbia University and University of Chicago Research office in Bangladesh, Dhaka, Bangladesh.
Akm Rabiul HasanColumbia University and University of Chicago Research office in Bangladesh, Dhaka, Bangladesh.
Habibul AhsanDepartment of Public Health Sciences, University of Chicago, Chicago, IL, USA.
Joseph H GrazianoDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
Rubhana RaqibInfectious Diseases Division, icddr,b, Dhaka, Bangladesh.
International Centre for Diarrhoeal Disease Research · BDUniversity of Chicago Research Bangladesh · BDColumbia University · USChicago Department of Public Health · US

Funding

Training CoreP42ES010349 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI NAVAS-ACIEN, ANA · 2000 to 2020
$53.6M
True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
Synergistic Immunosuppression by PAHs and ArseniteR01ES019968 · NIEHS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BURCHIEL, SCOTT W · 2012 to 2016
$2.9M
Arsenic Exposure, Impaired Respiratory Function, and ImmunosuppressionR01ES023888 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PARVEZ, MUHAMMAD F · 2015 to 2018
$1.8M
Enhancement and Maintenance of the HEALS cohortR24ES028532 · NIEHS · UNIVERSITY OF CHICAGO · PI AHSAN, HABIBUL · 2017 to 2022
$1.7M
NIEHS NIH HHS P30 ES009089NIEHS NIH HHS P30 ES027792NIEHS NIH HHS R01 ES019968NIEHS NIH HHS R01 ES023888
6 · The paper itself

Abstract

Early-life exposure to arsenic (As) increases risks of respiratory diseases/infections in children. However, data on the ability of the innate immune system to combat bacterial infections in the respiratory tracts of As-exposed children are scarce. To evaluate whether persistent low-dose As exposure alters innate immune function among children younger than 5 years-of-age, mothers and participating children (

Indexed as

Rural PopulationAntibodies, BacterialArsenicBangladeshChild, PreschoolEnvironmental ExposureFemaleHumansImmunity, InnateLongitudinal StudiesMacrophagesMaleMonocytesStreptococcus pneumoniaeAntibodies, BacterialArsenicArsenicLL-37macrophage functionrespiratory pathogensserum bactericidal antibody response

Identifiers

PMID31703545
PMCPMC7041495
OpenAlexW2986018412

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.