ArticleGeriatrics (Basel, Switzerland)2019
Malignant Transformation in Diabetic Foot Ulcers-Case Reports and Review of the Literature.
Article in Geriatrics (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- Neoplastic Foot Ulcers: A Multicentre Retrospective Study.International wound journal · 2026Article
- Squamous Cell Carcinoma Arising from Chronic Osteomyelitis: A Single-Center Case Series of Six Patients.Infection and drug resistance · 2026Article
- Understanding risk factors and prognosis in diabetic foot ulcers.Open life sciences · 2025Review
- Diabetic ulcer with cutaneous squamous cell carcinoma: A case report.World journal of clinical oncology · 2024Article
- Dichotomous role of miR193b-3p in diabetic foot ulcers maintains inhibition of healing and suppression of tumor formation.Science translational medicine · 2022Article
- Multifaceted functions of chronic inflammation in regulating tumor dormancy and relapse.Seminars in cancer biology · 2022Review
- A Rare Case of Invasive Keratinizing Squamous Cell Carcinoma of the Foot.International medical case reports journal · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An imbalance of regeneration and destruction of the extracellular matrix due to a plethora of chemo- and cytokines, elevated matrix metalloproteinases, bacterial contamination and repetitive painless tissue damage can lead the chronicity of a wound, especially in diabetic foot ulcers (DFU). Along general lines, wound healing and cancer development are similar. Therefore chronic wounds prepare a breeding ground for cancer development. Several characteristics such as increase in size, verrucous everted margins and contact bleeding are suspicious for malignant growth in a chronic wound. While previously the term Marjolin's ulcer was attributed to a malignant tumor in (burn) scars, it is nowadays used for every malignant tumor in chronic wounds. Furthermore, chronic ulcers in diabetic feet are susceptible for malignant transformation. We describe two cases of squamous cell carcinoma in patients with DFU-a 71 year-old woman and a 67 year old man. Both received total tumor excision and split-skin grafts with good short-time results.
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Registered trials
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