ArticleMetabolites2019
Untargeted Urinary
Article in Metabolites, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Metabolic Fingerprinting of Urine Reveals Metabolite Changes in Women With Breast Cancer.Cancer medicine · 2026Article
- Review
- Exploring the complex relationship between metabolomics and breast cancer early detection (Review).Molecular and clinical oncology · 2025Review
- Molecular Determinants in Seminal Plasma and Spermatozoa: Nontargeted Metabolomics.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Salivary Metabolites in Breast Cancer and Fibroadenomas: Focus on Menopausal Status and BMI.Metabolites · 2024Article
- Metabolomic Profiling of Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy for Predicting Disease-Free and Overall Survival.International journal of molecular sciences · 2024Article
- A Multiomics, Molecular Atlas of Breast Cancer Survivors.Metabolites · 2024Article
- Global untargeted and individual targeted plasma metabolomics of breast cancer recurrence modified by hormone receptors.Breast cancer (Tokyo, Japan) · 2024Article
- Emerging implications of bacterial biofilm in cancer biology: Recent updates and major perspectives.Gut microbes reports · 2024Review
- NMR-Based Metabolomics to Evaluate Individual Response to Treatments.Handbook of experimental pharmacology · 2023Article
- Review
- Urine Metabolomic Profile of Breast- versus Formula-Fed Neonates Using a Synbiotic-Enriched Formula.International journal of molecular sciences · 2022Article
- Tumor mutational burden presents limiting effects on predicting the efficacy of immune checkpoint inhibitors and prognostic assessment in adrenocortical carcinoma.BMC endocrine disorders · 2022Article
- Uncontrolled Thyroid during Pregnancy Alters the Circulative and Exerted Metabolome.International journal of molecular sciences · 2022Article
- Trimethylamine N-Oxide Promotes Cell Proliferation and Angiogenesis in Colorectal Cancer.Journal of immunology research · 2022Article
- Metabolomic Profiling of Blood-Derived Microvesicles in Breast Cancer Patients.International journal of molecular sciences · 2021Article
- An integrative approach based on GC-qMS and NMR metabolomics data as a comprehensive strategy to search potential breast cancer biomarkers.Metabolomics : Official journal of the Metabolomic Society · 2021Article
- Precision Oncology via NMR-Based Metabolomics: A Review on Breast Cancer.International journal of molecular sciences · 2021Review
- Using an Untargeted Metabolomics Approach to Identify Salivary Metabolites in Women with Breast Cancer.Metabolites · 2020Article
- Urinary metabolomic investigations in vitiligo patients.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Breast cancer (BC) remains the second leading cause of death among women worldwide. An emerging approach based on the identification of endogenous metabolites (EMs) and the establishment of the metabolomic fingerprint of biological fluids constitutes a new frontier in medical diagnostics and a promising strategy to differentiate cancer patients from healthy individuals. In this work we aimed to establish the urinary metabolomic patterns from 40 BC patients and 38 healthy controls (CTL) using proton nuclear magnetic resonance spectroscopy (1H-NMR) as a powerful approach to identify a set of BC-specific metabolites which might be employed in the diagnosis of BC. Orthogonal partial least squares-discriminant analysis (OPLS-DA) was applied to a 1H-NMR processed data matrix. Metabolomic patterns distinguished BC from CTL urine samples, suggesting a unique metabolite profile for each investigated group. A total of 10 metabolites exhibited the highest contribution towards discriminating BC patients from healthy controls (variable importance in projection (VIP) >1,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.