Evidence map›Paper›PMID 31703357›Full record

ArticleDiagnostics (Basel, Switzerland)2019

A Proteomic Study of Atherosclerotic Plaques in Men with Coronary Atherosclerosis.

Ekaterina M Stakhneva, Irina A Meshcheryakova, Evgeny A Demidov, Konstantin V Starostin, Evgeny V Sadovski, Sergey E Peltek, Michael I Voevoda, Alexander M Chernyavskii, Alexander M Volkov, Yuliya I Ragino

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Deciphering Acute Coronary Syndromes Pathobiology Through Proteomics.Journal of cardiovascular development and disease · 2025
    Review
  3. Review
  4. Review
  5. Macrophage Phenotyping in Atherosclerosis by Proteomics.International journal of molecular sciences · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Proteomic Studies of Blood and Vascular Wall in Atherosclerosis.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ekaterina M StakhnevaResearch Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 630089 Novosibirsk, Russia.ORCID 0000-0003-0484-6540
Irina A MeshcheryakovaInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Evgeny A DemidovInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Konstantin V StarostinInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.ORCID 0000-0002-7350-0394
Evgeny V SadovskiResearch Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 630089 Novosibirsk, Russia.ORCID 0000-0001-7350-534X
Sergey E PeltekInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Michael I VoevodaResearch Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 630089 Novosibirsk, Russia.
Alexander M ChernyavskiiThe Federal State Budgetary Institution "National Medical Research Center named academician E.N. Meshalkin" of the Ministry of Health of the Russian Federation, 630055 Novosibirsk, Russia.ORCID 0000-0002-0540-3357
Alexander M VolkovThe Federal State Budgetary Institution "National Medical Research Center named academician E.N. Meshalkin" of the Ministry of Health of the Russian Federation, 630055 Novosibirsk, Russia.
Yuliya I RaginoResearch Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 630089 Novosibirsk, Russia.ORCID 0000-0002-4936-8362
Institute of Cytology and Genetics · RUMinistry of Health of the Russian Federation · RU

Funding

budget theme on support of bioresource collections under the state task 0324-2017-0048budget theme on the state task АААА-А17-117112850280-2Российский Фонд Фундаментальных Исследований (РФФИ) 18-415-540006 p_a
6 · The paper itself

Abstract

backgroundTo study the changes in protein composition of atherosclerotic plaques at different stages of their development in coronary atherosclerosis using proteomics.

methodsThe object of research consisted of homogenates of atherosclerotic plaques from coronary arteries at different stages of development, obtained from 15 patients. Plaque proteins were separated by two-dimensional electrophoresis. The resultant protein spots were identified by the matrix-assisted laser desorption ionization method with peptide mass mapping.

resultsGroups of differentially expressed proteins, in which the amounts of proteins differed more than twofold (

conclusionThis proteomic study identifies the proteins present in atherosclerotic plaques of coronary arteries by comparing their proteomes at three different stages of plaque development during coronary atherosclerosis.

Indexed as

atherosclerosisatherosclerotic plaquemass spectrometryproteomicstropomyosin

Identifiers

PMID31703357
PMCPMC6963888
OpenAlexW2989453017

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.