ArticleJournal of clinical medicine2019
Cross-Sectional and Longitudinal Associations between Peak Expiratory Flow and Frailty in Older Adults.
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Towards a consensus definition of allostatic load: a multi-cohort, multi-system, multi-biomarker individual participant data (IPD) meta-analysis.Psychoneuroendocrinology · 2023Pooled it
- Personality associations with lung function and dyspnea: Evidence from six studies.Respiratory medicine · 2023Pooled it
- Lung function change and quantitative computed tomography measurements are associated with prospective frailty.ERJ open research · 2026Article
- Effects of Manual Therapy on Respiratory Function in Healthy Individuals: A Randomized, Sham-Controlled Clinical Trial of Efficacy and Safety.Healthcare (Basel, Switzerland) · 2026Article
- Association between frailty and chronic lung diseases in middle aged and older population.BMC public health · 2026Article
- Development and validation of a long-term survival prediction model for older adults with asthma.Archives of public health = Archives belges de sante publique · 2026Article
- Peak Expiratory Flow and Its Trajectories Associated With Frailty in Older Adults: A Prospective Cohort Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- Association of Frailty with Ultrasound Parameters of Diaphragm Function in 153 Elderly Individuals.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- The relationship between lung function and headache risk in middle-aged and older adults: a cross-sectional and longitudinal study.European journal of medical research · 2025Article
- Associations Between Peak Expiratory Flow and Community Mobility Loss Among Older Adults in the United States.Journal of the American Geriatrics Society · 2025Article
- Association between chronic respiratory diseases and frailty in Chinese elderly: a population-based longitudinal study.BMJ open respiratory research · 2025Article
- Lung function in relation to brain aging and cognitive transitions in older adults: A population-based cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Association between physical activity, peak expiratory flow, and cognitive function in aging: a cross-sectional analysis.BMC geriatrics · 2024Article
- Lung function and the risk of frailty in the European population: a mendelian randomization study.European journal of medical research · 2024Article
- Associations between peak expiratory flow and frailty in olderly individuals: findings from the China health and retirement longitudinal study.Frontiers in public health · 2024Article
- Association of peak expiratory flow with motoric cognitive risk syndrome among older adults.Frontiers in aging neuroscience · 2024Article
- Portals to frailty? Data-driven analyses detect early frailty profiles.Alzheimer's research & therapy · 2021Article
- Frailty and chronic respiratory disease: the need for a multidisciplinary care model.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2021Article
- Reference Values and Related Factors for Peak Expiratory Flow in Middle-Aged and Elderly Chinese.Frontiers in public health · 2021Article
- Respiratory Sarcopenia and Sarcopenic Respiratory Disability: Concepts, Diagnosis, and Treatment.The journal of nutrition, health & aging · 2021Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Peak expiratory flow (PEF) has been linked to several health-related outcomes in older people, but its association with frailty is still unclear. This study investigates the association between PEF and prevalent and incident frailty in older adults. Data come from 2559 community-dwelling participants (age ≥ 60 years) of the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K). Baseline PEF was expressed as standardized residual (SR) percentiles. Frailty was assessed at baseline and over six years, according to the Fried criteria. Associations between PEF and frailty were estimated cross-sectionally through logistic regressions, and longitudinally by multinomial logistic regression, considering death as alternative outcome. Obstructive respiratory diseases and smoking habits were treated as potential effect modifiers. Our cross-sectional results showed that the 10th-49th and <10th PEF SR percentile categories were associated with three- and five-fold higher likelihood of being frail than the 80th-100th category. Similar estimates were confirmed longitudinally, i.e., adjusted OR = 3.11 (95% CI: 1.61-6.01) for PEF SR percentiles < 10th, compared with 80th-100th percentiles. Associations were enounced in participants without physical deficits, and tended to be stronger among those with baseline obstructive respiratory diseases, and, longitudinally, also among former/current smokers. These findings suggest that PEF is a marker of general robustness in older adults, and its reduction exceeding that expected by age is associated with frailty development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.