Evidence map›Paper›PMID 31703244›Full record

ArticleGenes2019

Aida Orois, Sudheer K Gara, Mireia Mora, Irene Halperin, Sandra Martínez, Rocio Alfayate, Electron Kebebew, Josep Oriola

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Genes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Genetic susceptibility to hereditary non-medullary thyroid cancer.Hereditary cancer in clinical practice · 2022
    Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Aida OroisDepartment of Endocrinology and Nutrition, ICMDM, Hospital Clinic, 08036 Barcelona, Spain.ORCID 0000-0001-7897-7899
Sudheer K GaraThoracic Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Mireia MoraDepartment of Endocrinology and Nutrition, ICMDM, Hospital Clinic, 08036 Barcelona, Spain.
Irene HalperinDepartment of Endocrinology and Nutrition, ICMDM, Hospital Clinic, 08036 Barcelona, Spain.
Sandra MartínezDepartment of Endocrinology and Nutrition, Hospital de Elda, 03600 Elda, Alicante, Spain.
Rocio AlfayateDepartment of Endocrinology and Nutrition, Hospital General Universitario de Alicante, 03010 Alicante, Spain.
Electron KebebewDepartment of Surgery and Stanford Cancer Institute, Stanford University, Stanford, CA 9430, USA.
Josep OriolaFaculty of Medicine, University of Barcelona, 08007 Barcelona, Spain.
Hospital Clínic de Barcelona · ESHospital General de Elda · ESHospital General Universitario de Alicante Doctor Balmis · ESNational Institutes of Health · USStanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonsyndromic familial non-medullary thyroid cancer (FNMTC) represents 3-9% of thyroid cancers, but the susceptibility gene(s) remain unknown. We designed this multicenter study to analyze families with nonsyndromic FNMTC and identify candidate susceptibility genes. We performed exome sequencing of DNA from four affected individuals from one kindred, with five cases of nonsyndromic FNMTC. Single Nucleotide Variants, and insertions and deletions that segregated with all the affected members, were analyzed by Sanger sequencing in 44 additional families with FNMTC (37 with two affected members, and seven with three or more affected members), as well as in an independent control group of 100 subjects. We identified the germline variant p. Asp31His in

Indexed as

Genes, ModifierPolymorphism, Single NucleotideCell Line, TumorFemaleGerm-Line MutationHumansMaleMutation, MissensePedigreePenetranceThyroid GlandThyroid NeoplasmsTumor Suppressor ProteinsNOP53 protein, humanTumor Suppressor Proteinsgenetic abnormalitiesmolecular testingNOP53oncogenic mutationsthyroid cancer

Identifiers

PMID31703244
PMCPMC6896177
OpenAlexW2985045684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.