Evidence map›Paper›PMID 31703155›Full record

ArticleMagnetic resonance in medicine2020

Repeatability of radiomics and machine learning for DWI: Short-term repeatability study of 112 patients with prostate cancer.

Harri Merisaari, Pekka Taimen, Rakesh Shiradkar, Otto Ettala, Marko Pesola, Jani Saunavaara, Peter J Boström, Anant Madabhushi, Hannu J Aronen, Ivan Jambor

Registry-linked trialOpen access · greenAbstract readClinical Study
In one paragraph

Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05024162 (Can Magnetic Resonance Imaging of the Prostate Combined With a Radiomics Evaluation Determine the Invasive Capacity of a Tumour), which is not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05024162 narecruitingnot on this mapstarted 2022, after this paper: background citation

Can Magnetic Resonance Imaging of the Prostate Combined With a Radiomics Evaluation Determine the Invasive Capacity of a Tumour (Can MRI-PREDICT)

TypeinterventionalSponsorNova Scotia Health AuthorityRan2022 to 2025Enrolled60ConditionsProstate CancerArmsMRT Accuracy, MRT Stability
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Harri MerisaariDepartment of Diagnostic Radiology, University of Turku, Turku, Finland.ORCID 0000-0002-8515-5399
Pekka TaimenInstitute of Biomedicine, University of Turku, Turku, Finland.
Rakesh ShiradkarDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.
Otto EttalaDepartment of Urology, University of Turku and Turku University hospital, Turku, Finland.
Marko PesolaDepartment of Diagnostic Radiology, University of Turku, Turku, Finland.
Jani SaunavaaraMedical Imaging Centre of Southwest Finland, Turku University Hospital, Turku, Finland.
Peter J BoströmDepartment of Urology, University of Turku and Turku University hospital, Turku, Finland.
Anant MadabhushiDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.
Hannu J AronenDepartment of Diagnostic Radiology, University of Turku, Turku, Finland.
Ivan JamborDepartment of Diagnostic Radiology, University of Turku, Turku, Finland.ORCID 0000-0001-6305-3570
University of Turku · FICase Western Reserve University · USTurku University Hospital · FI

Funding

Computerized histologic image predictor of cancer outcomeR01CA202752 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI FELDMAN, MICHAEL D, GANESAN, SHRIDAR · 2016 to 2020
$3.1M
Quantitative Histomorphometric Risk Classifier (QuHbIC) in HPV + Oropharyngeal CarcinomaR01CA220581 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI KOYFMAN, SHLOMO, LEWIS, JAMES · 2018 to 2023
$3.1M
Computerized Histologic Risk Predictor (CHiRP) for Early Stage Lung CancersR01CA216579 · NCI · EMORY UNIVERSITY · PI FU, PINGFU, LLOYD, MARK · 2018 to 2023
$3.1M
MR Fingerprinting and Computerized Decision Support for Prostate CancerR01CA208236 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GULANI, VIKAS, PONSKY, LEE EVAN · 2017 to 2022
$3.0M
Pathology Image Informatics Platform for visualization, analysis and managementU24CA199374 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI GURCAN, METIN NAFI, MADABHUSHI, ANANT · 2015 to 2019
$2.9M
HistoTools: A suite of digital pathology tools for quality control, annotation and dataset identificationU01CA239055 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI JANOWCZYK, ANDREW ROBERT, MADABHUSHI, ANANT · 2019 to 2022
$1.0M
RadIO: A Novel Radiomics Toolkit to Predict and Characterize Response to Immunotherapy in Stage III Non-Small Cell Lung CancerI01BX004121 · VA · VETERANS HEALTH ADMINISTRATION · PI Anant Madabhushi, Charles J Nock · 2019 to 2026
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BIOMEDICAL ENGINEERING RESEARCH FACILITIESC06RR012463 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI KUTINA, KENNETH L · 1997 to 1997
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BLRD VA I01 BX004121NCI NIH HHS R01 CA202752NCI NIH HHS R01 CA208236NCI NIH HHS R01 CA216579NCI NIH HHS R01 CA220581NCI NIH HHS U01 CA239055NCI NIH HHS U24 CA199374NCRR NIH HHS C06 RR012463
6 · The paper itself

Abstract

purposeTo evaluate repeatability of prostate DWI-derived radiomics and machine learning methods for prostate cancer (PCa) characterization.

methodsA total of 112 patients with diagnosed PCa underwent 2 prostate MRI examinations (Scan1 and Scan2) performed on the same day. DWI was performed using 12 b-values (0-2000 s/mm

resultsThe ICC(3,1) values for conventional radiomics and feature pruning methods were in the range of 0.28-0.90. The machine learning classifications varied between Scan1 and Scan2 with % of same class labels between Scan1 and Scan2 in the range of 61-81%. Surface-to-volume ratio and corner detector-based features were among the most represented features with high repeatability, ICC(3,1) >0.75, consistently high ranking using all 4 feature pruning methods, and classification performance with area under the receiver operator characteristic curve >0.70.

conclusionSurface-to-volume ratio and corner detectors for prostate DWI led to good classification of unseen data and performed similarly in Scan1 and Scan2 in contrast to multiple conventional radiomic features.

Indexed as

Prostatic NeoplasmsHumansMachine LearningMaleNeoplasm GradingProstatectomycorner detectiondiffusion-weighted imagingfeature extractionGleason scoreintraclass correlation coefficientmachine learningprostate cancerradiomicsrepeatabilityshape

Identifiers

PMID31703155
PMCPMC7047644
OpenAlexW2983255478

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.