Evidence map›Paper›PMID 31702972›Full record

ReviewAmerican journal of physiology. Heart and circulatory physiology2020

Disentangling the Gordian knot of local metabolic control of coronary blood flow.

Johnathan D Tune, Adam G Goodwill, Alexander M Kiel, Hana E Baker, Shawn B Bender, Daphne Merkus, Dirk J Duncker

Open access · bronzeAbstract readReview
In one paragraph

Review in American journal of physiology. Heart and circulatory physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Unraveling the Gordian knot of coronary pressure-flow autoregulation.Journal of molecular and cellular cardiology · 2024
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Johnathan D TuneDepartment of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana.ORCID 0000-0003-2959-0801
Adam G GoodwillDepartment of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana.ORCID 0000-0003-3701-3713
Alexander M KielWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana.
Hana E BakerDepartment of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana.
Shawn B BenderBiomedical Sciences, University of Missouri, Columbia, Missouri.ORCID 0000-0003-4709-1387
Daphne MerkusDivision of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Cardiovascular Research School Erasmus University Rotterdam, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID 0000-0002-4852-831X
Dirk J DunckerDivision of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Cardiovascular Research School Erasmus University Rotterdam, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID 0000-0003-2836-2241
Indiana University School of MedicineErasmus University Rotterdam · NLGerman Centre for Cardiovascular Research · DEHarry S. Truman Memorial Veterans' Hospital · USPurdue University West Lafayette · US

Funding

Translation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina · 2015 to 2026
$17.4M
Indiana Medical Scientist/Engineer Training ProgramT32GM077229 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI GASTON, BENJAMIN, HERBERT, BRITTNEY-SHEA · 2008 to 2022
$6.0M
Mineralocorticoid receptor-dependent coronary vascular dysfunction in obesityR01HL136386 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI BENDER, SHAWN BRADY · 2018 to 2022
$2.8M
NHLBI NIH HHS R01 HL136386NIDDK NIH HHS P30 DK097512NIGMS NIH HHS T32 GM077229
6 · The paper itself

Abstract

Recognition that coronary blood flow is tightly coupled with myocardial metabolism has been appreciated for well over half a century. However, exactly how coronary microvascular resistance is tightly coupled with myocardial oxygen consumption (MV̇o

Indexed as

Coronary CirculationEnergy MetabolismHemodynamicsOxygen ConsumptionAnimalsCardiovascular DiseasesCoronary VesselsDisease Models, AnimalHumansModels, CardiovascularMyocardiumSpecies Specificitycoronary circulationcoronary venous Po2local metabolic controlmyocardial oxygen consumption

Identifiers

PMID31702972
PMCPMC7199237
OpenAlexW2985797153

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.