ArticleCytoskeleton (Hoboken, N.J.)2020
dTACC restricts bouton addition and regulates microtubule organization at the Drosophila neuromuscular junction.
Article in Cytoskeleton (Hoboken, N.J.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Dynein-driven regulation of postsynaptic membrane architecture and synaptic function.Journal of cell science · 2025Article
- Neuronal LRP4 directs the development, maturation and cytoskeletal organization of Drosophila peripheral synapses.Development (Cambridge, England) · 2024Article
- Patronin regulates presynaptic microtubule organization and neuromuscular junction development iniScience · 2024Article
- Neuronal LRP4 directs the development, maturation, and cytoskeletal organization of peripheral synapses.bioRxiv : the preprint server for biology · 2023Article
- FMRP activity and control of Csw/SHP2 translation regulate MAPK-dependent synaptic transmission.PLoS biology · 2023Article
- Mask, the Drosophila ankyrin repeat and KH domain-containing protein, affects microtubule stability.Journal of cell science · 2021Article
- dTACC restricts bouton addition and regulates microtubule organization at the Drosophila neuromuscular junction.Cytoskeleton (Hoboken, N.J.) · 2020Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Regulation of the synaptic cytoskeleton is essential to proper neuronal development and wiring. Perturbations in neuronal microtubules (MTs) are associated with numerous pathologies, yet it remains unclear how changes in MTs may be coupled to synapse morphogenesis. Studies have identified many MT regulators that promote synapse growth. However, less is known about the factors that restrict growth, despite the potential links of synaptic overgrowth to severe neurological conditions. Here, we report that dTACC, which is implicated in MT assembly and stability, prevents synapse overgrowth at the Drosophila neuromuscular junction by restricting addition of new boutons throughout larval development. dTACC localizes to the axonal MT lattice and is required to maintain tubulin levels and the integrity of higher-order MT structures in motor axon terminals. While previous reports have demonstrated the roles of MT-stabilizing proteins in promoting synapse growth, our findings suggest that in certain contexts, MT stabilization may correlate with restricted growth.
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