Evidence map›Paper›PMID 31702553›Full record

ArticleeLife2019

Late developing cardiac lymphatic vasculature supports adult zebrafish heart function and regeneration.

Michael Rm Harrison, Xidi Feng, Guqin Mo, Antonio Aguayo, Jessi Villafuerte, Tyler Yoshida, Caroline A Pearson, Stefan Schulte-Merker, Ching-Ling Lien

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 90 citations in OpenAlex.

  1. Article
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  4. Signal control during tissue regeneration in adult animals.Nature reviews. Molecular cell biology · 2026
    Review
  5. Article
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  7. Emerging Light-Sheet Fluorescence Microscopy for Cardiac Vascular Imaging in Zebrafish.Current treatment options in cardiovascular medicine · 2026
    Review
  8. Article
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Michael Rm HarrisonThe Saban Research Institute of Children's Hospital Los Angeles, Los Angeles, United States.ORCID 0000-0003-1703-9879
Xidi FengThe Saban Research Institute of Children's Hospital Los Angeles, Los Angeles, United States.
Guqin MoThe Saban Research Institute of Children's Hospital Los Angeles, Los Angeles, United States.
Antonio AguayoThe Saban Research Institute of Children's Hospital Los Angeles, Los Angeles, United States.
Jessi VillafuerteThe Saban Research Institute of Children's Hospital Los Angeles, Los Angeles, United States.
Tyler YoshidaThe Saban Research Institute of Children's Hospital Los Angeles, Los Angeles, United States.
Caroline A PearsonDepartment of Neurobiology, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Stefan Schulte-MerkerInstitute of Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, University of Münster, Münster, Germany.ORCID 0000-0003-3617-8807
Ching-Ling LienThe Saban Research Institute of Children's Hospital Los Angeles, Los Angeles, United States.ORCID 0000-0002-5100-9780
Children's Hospital of Los Angeles · USUniversity of Southern California · USUniversity of California, Los Angeles · USUniversity of Münster · DE

Funding

Cxc12 chemokine signaling regulates synchronous development of coronary vessels and myocardiumR01HL130172 · NHLBI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI LIEN, CHING-LING E · 2017 to 2020
$1.7M
American Heart Association I81PA34180044California Institute for Regenerative Medicine EDUC2-08418Children's Hospital Los Angeles 2nd R01 and Team AwardsDeutsche Forschungsgemeinschaft CRC 1348NHLBI NIH HHS 1R01HL130172NHLBI NIH HHS R01 HL130172
6 · The paper itself

Abstract

The cardiac lymphatic vascular system and its potentially critical functions in heart patients have been largely underappreciated, in part due to a lack of experimentally accessible systems. We here demonstrate that cardiac lymphatic vessels develop in young adult zebrafish, using coronary arteries to guide their expansion down the ventricle. Mechanistically, we show that in

Indexed as

AnimalsAnimals, Genetically ModifiedCoronary VesselsGene Expression Regulation, DevelopmentalHeartHumansLymphangiogenesisLymphatic VesselsMutationMyocardiumReceptors, CXCR4RegenerationVascular Endothelial Growth Factor CVascular Endothelial Growth Factor Receptor-3ZebrafishZebrafish ProteinsCXCR4a protein, zebrafishReceptors, CXCR4Vascular Endothelial Growth Factor Cvascular endothelial growth factor C, zebrafishVascular Endothelial Growth Factor Receptor-3Zebrafish Proteinscardiac lymphaticscryoinjurydevelopmental biologyregenerationregenerative medicinerevascularizationstem cellszebrafish

Identifiers

PMID31702553
PMCPMC6881116
OpenAlexW2988681350

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.