Evidence map›Paper›PMID 31702551›Full record

ArticleCanadian Urological Association journal = Journal de l'Association des urologues du Canada2020

Outcomes of trimodality bladder-sparing therapy for muscle-invasive bladder cancer.

Eric K Nguyen, Hang Yu, Gregory Pond, Bobby Shayegan, Jehonathan H Pinthus, Anil Kapoor, Som D Mukherjee, Alan Neville, Aly-Khan A Lalani, Sebastien J Hotte and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Eric K NguyenDivision of Radiation Oncology, McMaster University, Hamilton, ON, Canada.
Hang YuMichael DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
Gregory PondEscarpment Cancer Research Institute, McMaster University, Hamilton, ON, Canada.
Bobby ShayeganDivision of Urology, Department of Surgery, McMaster University, Hamilton, ON, Canada.
Jehonathan H PinthusDivision of Urology, Department of Surgery, McMaster University, Hamilton, ON, Canada.
Anil KapoorDivision of Urology, Department of Surgery, McMaster University, Hamilton, ON, Canada.
Som D MukherjeeDivision of Medical Oncology, McMaster University, Hamilton, ON, Canada.
Alan NevilleDivision of Medical Oncology, McMaster University, Hamilton, ON, Canada.
Aly-Khan A LalaniDivision of Medical Oncology, McMaster University, Hamilton, ON, Canada.
Sebastien J HotteDivision of Medical Oncology, McMaster University, Hamilton, ON, Canada.
Thomas B CorbettDivision of Radiation Oncology, McMaster University, Hamilton, ON, Canada.
Ian S DayesDivision of Radiation Oncology, McMaster University, Hamilton, ON, Canada.
Himanshu R LukkaDivision of Radiation Oncology, McMaster University, Hamilton, ON, Canada.
McMaster University · CAMcMaster University Medical Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAlthough radical cystectomy is considered the standard of care for muscle-invasive bladder cancer (MIBC), recent data has suggested comparable survival outcomes for bladder-sparing trimodality therapy (TMT). We conducted a retrospective, single-institution analysis of MIBC patients to evaluate the efficacy of TMT as an alternative, curative approach to surgical intervention.

methodsWe conducted a retrospective analysis of MIBC patients assessed by a multidisciplinary team at the Juravinski Cancer Centre from 2010-2016. Patients underwent transurethral resection of bladder tumor (TURBT) followed by radiotherapy with or without concurrent chemotherapy. Patients could receive neoadjuvant treatment. Clinical data and response rates were summarized, and overall survival (OS) and disease-free survival (DFS) were estimated using the Kaplan-Meier method.

resultsOur analytic cohort included 115 patients, of whom 53 underwent TMT and 62 underwent radiotherapy alone following TURBT. Median age at diagnosis was 79 years and median followup was 21 months. Complete response rates in those receiving TMT and radiation without chemotherapy were 84.4% and 66.7%, respectively. For TMT patients, three-year OS and DFS were 68.5% and 49.6%, respectively. Patients who received TMT had reduction in risk of mortality (hazard ratio [HR] 0.49; p=0.026) and disease recurrence (HR 0.55; p=0.017) compared to those who had radiation without chemotherapy. Overall, four patients had grade 3 or higher late toxicity.

conclusionsIn this single-institution analysis, TMT appears to be a safe and effective approach in the short-term management of MIBC in appropriately selected patients. Extended followup and analysis are necessary to validate these results.

Identifiers

PMID31702551
PMCPMC7124184
OpenAlexW2985585348

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.