ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2020
Oesophageal eosinophilia accompanies food allergy to hen egg white protein in young pigs.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 15 citations in OpenAlex.
- Roles of systemic CD4Research square · 2026Article
- Mouse models of eosinophilic esophagitis: molecular and translational insights.American journal of physiology. Gastrointestinal and liver physiology · 2025Review
- Comparison of histochemical methods for the analysis of eosinophils and mast cells using a porcine model of eosinophilic esophagitis.Frontiers in veterinary science · 2025Article
- Animal models of eosinophilic esophagitis.Journal of leukocyte biology · 2024Review
- Animal models of eosinophilic esophagitis, review and perspectives.Animal models and experimental medicine · 2024Review
- Eosinophils Infiltration in Esophageal Muscularis Propria Induces Achalasia-like Esophageal Motility Disorder in Mice.Biomolecules · 2022Article
- Immunologic and pathologic characterization of a novel swine biomedical research model for eosinophilic esophagitis.Frontiers in allergy · 2022Article
- Steroid Eluting Esophageal-Targeted Drug Delivery Devices for Treatment of Eosinophilic Esophagitis.Polymers · 2021Article
- The Role of B Cells and Antibodies in Eosinophilic Esophagitis.Inflammatory intestinal diseasesReview
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10 authors at 2 institutions in 1 country.
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Abstract
backgroundEsophagitis with eosinophilia, inflammation, and fibrosis represent a chronic condition in humans with food allergies.
objectiveIn this investigation, we asked whether esophagitis with an eosinophilic component is observed in young pigs rendered allergic to hen egg white protein (HEWP).
methodsFood allergy was induced in young pigs using two protocols. In one protocol, sensitized pigs were challenged by gavage with a single dose of HEWP. Clinical signs were monitored for 24 hours, and then, gastrointestinal (GI) tissues were collected for histological examination. The phenotype of circulating, ovalbumin (OVA)-specific T cells also was examined in HEWP challenged animals. In the second protocol, sensitized animals were fed HEWP for 28 days. Animals were then examined by endoscopy and gastrointestinal tissues collected for histological examination.
resultsIn pigs challenged by gavage with HEWP, clinical signs were noted in 5/6 pigs including diarrhoea, emesis, and skin rash. Clinical signs were not seen in any control group. Histological analysis revealed significant levels of oesophageal eosinophilic infiltration (P < .05) in 4/6 of these animals, with two also displaying eosinophilic infiltration in the stomach. Eosinophils were not increased in ileum or colon samples. Increased numbers of circulating, OVA-specific CD4 CONCLUSIONS AND CLINICAL RELEVANCE: Food allergy in the pig can be associated with esophagitis based on histological and endoscopic findings, including eosinophilic infiltration. The young pig may, therefore, be a useful large animal model for the study of eosinophilic esophagitis in humans.
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