ArticleSleep2020
The spectral fingerprint of sleep problems in post-traumatic stress disorder.
Article in Sleep, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 44 citations in OpenAlex.
- Impaired slow-wave sleep accounts for brain aging-related increases in anxiety.Communications psychology · 2026Article
- The impact of trauma and how to intervene: a narrative review of psychotraumatology over the past 15 years.European journal of psychotraumatology · 2025Article
- A Permutation Entropy Method for Sleep Disorder Screening.Brain sciences · 2025Article
- Heartbeat-related activity in the anterior thalamus differs between phasic and tonic REM sleep.The Journal of physiology · 2025Article
- Statistical Complexity Analysis of Sleep Stages.Entropy (Basel, Switzerland) · 2025Article
- A model for secondary traumatic stress following workplace exposure to traumatic material in analytical staff.Communications psychology · 2024Review
- Sex differences in body temperature and neural power spectra in response to repeated restraint stress.Stress (Amsterdam, Netherlands) · 2024Article
- Targeting sleep quality in acutely traumatized individuals to reduce the risk for PTSD: study protocol for a multicentre randomized clinical trial.European journal of psychotraumatology · 2024Article
- The importance of REM sleep fragmentation in the effects of stress on sleep: Perspectives from preclinical studies.Neurobiology of stress · 2024Article
- Beta spectral power during sleep is associated with impaired recall of extinguished fear.Sleep · 2023Article
- Sleep spindles, stress and PTSD: The state of the science and future directions.Neurobiology of stress · 2023Article
- Sleep Latency and Post-Traumatic Stress Disorder Among Retired Career Florida Firefighters: Evidence From the Advancing Epidemiology of Retired Firefighters Aging Longitudinally Cohort.Journal of occupational and environmental medicine · 2022Article
- Autonomic regulation during sleep in PTSD.Neurobiology of stress · 2022Article
- Article
- Abnormal rapid eye movement sleep atonia control in chronic post-traumatic stress disorder.Sleep · 2022Article
- The association of polysomnographic sleep on posttraumatic stress disorder symptom clusters in trauma-exposed civilians and veterans.Sleep advances : a journal of the Sleep Research Society · 2022Article
- The Many Faces of Sleep Disorders in Post-Traumatic Stress Disorder: An Update on Clinical Features and Treatment.Neuropsychobiology · 2022Review
- Circadian influence on intrusive re-experiencing in trauma survivors' daily lives.European journal of psychotraumatology · 2022Article
- Sleep and PTSD in the Military Forces: A Reciprocal Relationship and a Psychiatric Approach.Brain sciences · 2021Review
- Relationship between the Spectral Power Density of Sleep Electroencephalography and Psychiatric Symptoms in Patients with Breathing-related Sleep Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesSleep problems are a core feature of post-traumatic stress disorder (PTSD). The aim of this study was to find a robust objective measure for the sleep disturbance in patients having PTSD.
methodsThe current study assessed EEG power across a wide frequency range and multiple scalp locations, in matched trauma-exposed individuals with and without PTSD, during rapid eye movement (REM) and non-REM (NREM) sleep. In addition, a full polysomnographical evaluation was performed, including sleep staging and assessment of respiratory function, limb movements, and heart rate. The occurrence of sleep disorders was also assessed.
resultsIn patients having PTSD, NREM sleep shows a substantial loss of slow oscillation power and increased higher frequency activity compared with controls. The change is most pronounced over right-frontal sensors and correlates with insomnia. PTSD REM sleep shows a large power shift in the opposite direction, with increased slow oscillation power over occipital areas, which is strongly related to nightmare activity and to a lesser extent with insomnia. These pronounced spectral changes occur in the context of severe subjective sleep problems, increased occurrence of various sleep disorders and modest changes in sleep macrostructure.
conclusionsThis is the first study to show pronounced changes in EEG spectral topologies during both NREM and REM sleep in PTSD. Importantly, the observed power changes reflect the hallmarks of PTSD sleep problems: insomnia and nightmares and may thus be specific for PTSD. A spectral index derived from these data distinguishes patients from controls with high effect size, bearing promise as a candidate biomarker.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.