ArticleJournal of neurotrauma2020
Biomechanics of Periventricular Injury.
Article in Journal of neurotrauma, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 56 citations in OpenAlex.
- Regional ventricular enlargement as an in vivo biomarker of cumulative biomechanical neurodegeneration in former American football players.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Development of a paediatric model of diffuse traumatic brain injury in ferrets.Scientific reports · 2026Article
- Axonal tract-integrated finite element brain model for predicting mild traumatic brain injury based on axonal strain.Frontiers in bioengineering and biotechnology · 2026Article
- Surface-based versus voxel-based finite element head models: comparative analyses of strain responses.Biomechanics and modeling in mechanobiology · 2025Article
- Peaks and Distributions of White Matter Tract-related Strains in Bicycle Helmeted Impacts: Implication for Helmet Ranking and Optimization.Annals of biomedical engineering · 2025Article
- A Spatial Interpolation Approach to Assign Magnetic Resonance Imaging-Derived Material Properties for Finite Element Models of Adeno-Associated Virus Infusion Into a Recurrent Brain Tumor.Journal of biomechanical engineering · 2024Article
- Mechanical loading of the ventricular wall as a spatial indicator for periventricular white matter degeneration.Journal of the mechanical behavior of biomedical materials · 2023Article
- Traumatic Brain Injury Induces Microglial and Caspase3 Activation in the Retina.International journal of molecular sciences · 2023Article
- In Situ Strain Measurements Within Helmet Padding During Linear Impact Testing.Annals of biomedical engineering · 2022Article
- Use of Brain Biomechanical Models for Monitoring Impact Exposure in Contact Sports.Annals of biomedical engineering · 2022Review
- 3D finite-element brain modeling of lateral ventricular wall loading to rationalize periventricular white matter hyperintensity locations.Engineering with computers · 2022Article
- The Presence of the Temporal Horn Exacerbates the Vulnerability of Hippocampus During Head Impacts.Frontiers in bioengineering and biotechnology · 2022Article
- Peak ependymal cell stretch overlaps with the onset locations of periventricular white matter lesions.Scientific reports · 2021Article
- Instantaneous Whole-Brain Strain Estimation in Dynamic Head Impact.Journal of neurotrauma · 2021Article
- Hybrid diffusion imaging reveals altered white matter tract integrity and associations with symptoms and cognitive dysfunction in chronic traumatic brain injury.NeuroImage. Clinical · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periventricular injury is frequently noted as one aspect of severe traumatic brain injury (TBI) and the presence of the ventricles has been hypothesized to be a primary pathogenesis associated with the prevalence of periventricular injury in patients with TBI. Although substantial endeavors have been made to elucidate the potential mechanism, a thorough explanation for this hypothesis appears lacking. In this study, a three-dimensional (3D) finite element (FE) model of the human head with an accurate representation of the cerebral ventricles is developed accounting for the fluid properties of the intraventricular cerebrospinal fluid (CSF) as well as its interaction with the brain. An additional model is developed by replacing the intraventricular CSF with a substitute with brain material. Both models are subjected to rotational accelerations with magnitudes suspected to induce severe diffuse axonal injury. The results reveal that the presence of the ventricles leads to increased strain in the periventricular region, providing a plausible explanation for the vulnerability of the periventricular region. In addition, the strain-exacerbation effect associated with the presence of the ventricles is also noted in the paraventricular region, although less pronounced than that in the periventricular region. The current study advances the understanding of the periventricular injury mechanism as well as the detrimental effects that the ventricles exert on the periventricular and paraventricular brain tissue.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.