Evidence map›Paper›PMID 31701784›Full record

ArticleJournal of the American Heart Association2019

Risk of Major Adverse Cardiovascular Events and Major Hemorrhage Among White and Black Patients Undergoing Percutaneous Coronary Intervention.

Anping Cai, Chrisly Dillon, William B Hillegass, Mark Beasley, Brigitta C Brott, Vera A Bittner, Gilbert J Perry, Ganesh V Halade, Sumanth D Prabhu, Nita A Limdi

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Racial/Ethnic, Sex, and Economic Disparities in the Utilization and Outcomes of Intracoronary Imaging.Journal of the Society for Cardiovascular Angiography & Interventions · 2024
    Article
  11. Article
  12. Review
  13. Evaluation of Potential Racial Disparities in CYP2C19-Guided P2YClinical pharmacology and therapeutics · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Anping CaiDepartment of Neurology University of Alabama at Birmingham AL.
Chrisly DillonDepartment of Neurology University of Alabama at Birmingham AL.
William B HillegassDepartment of Data Science and Medicine University of Mississippi Medical Center Jackson MS.
Mark BeasleyDepartment of Biostatistics University of Alabama at Birmingham AL.
Brigitta C BrottDivision of Cardiovascular Diseases Department of Medicine University of Alabama at Birmingham AL.
Vera A BittnerDivision of Cardiovascular Diseases Department of Medicine University of Alabama at Birmingham AL.
Gilbert J PerryDivision of Cardiovascular Diseases Department of Medicine University of Alabama at Birmingham AL.
Ganesh V HaladeDivision of Cardiovascular Diseases Department of Medicine University of Alabama at Birmingham AL.
Sumanth D PrabhuDivision of Cardiovascular Diseases Department of Medicine University of Alabama at Birmingham AL.
Nita A LimdiDepartment of Neurology University of Alabama at Birmingham AL.
University of Alabama at Birmingham · USUniversity of Mississippi Medical Center · US

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI HALL, JOHN E · 2016 to 2025
$38.2M
Predictors of hemorrhage among patients on direct acting oral anticoagulantsR01HL092173 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LIMDI, NITA A · 2008 to 2023
$10.4M
UAB Center for Clinical and Translational Science (CCTS) UL1UL1TR000165 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2012 to 2013
$9.6M
Patient Oriented Research in Personalized Antithrombotic TherapyK24HL133373 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LIMDI, NITA A · 2016 to 2025
$1.2M
NCATS NIH HHS UL1 TR000165NHLBI NIH HHS K24 HL133373NHLBI NIH HHS R01 HL092173NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

Background Data on racial disparities in major adverse cardiovascular events (MACE) and major hemorrhage (HEM) after percutaneous coronary intervention are limited. Factors contributing to these disparities are unknown. Methods and Results PRiME-GGAT (Pharmacogenomic Resource to Improve Medication Effectiveness-Genotype-Guided Antiplatelet Therapy) is a prospective cohort. Patients aged ≥18 years undergoing percutaneous coronary intervention were enrolled and followed for up to 1 year. Racial disparities in risk of MACE and HEM were assessed using an incident rate ratio. Sequential cumulative adjustment analyses were performed to identify factors contributing to these disparities. Data from 919 patients were included in the analysis. Compared with white patients, black patients (n=203; 22.1% of the cohort) were younger and were more likely to be female, to be a smoker, and to have higher body mass index, lower socioeconomic status, higher prevalence of diabetes mellitus and moderate to severe chronic kidney disease, and presentation with acute coronary syndrome and to undergo urgent percutaneous coronary intervention. The incident rates of MACE (34.1% versus 18.2% per 100 person-years,

Indexed as

Percutaneous Coronary InterventionSocial ClassAcute Coronary SyndromeAgedAge DistributionBlack or African AmericanBody Mass IndexCause of DeathComorbidityCoronary StenosisDiabetes MellitusEducational StatusFemaleHealth Status DisparitiesHumansIncidencecoronary heart diseasehealth disparitiesoutcomepercutaneous coronary interventionrace

Identifiers

PMID31701784
PMCPMC6915255
OpenAlexW2985865224

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.