Evidence map›Paper›PMID 31701782›Full record

ReviewExpert opinion on biological therapy2020

Therapeutic potential of mesenchymal stem/stromal cell-derived secretome and vesicles for lung injury and disease.

Airan Liu, Xiwen Zhang, Hongli He, Li Zhou, Yoshifumi Naito, Shinji Sugita, Jae-Woo Lee

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Expert opinion on biological therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04798716 (Mesenchymal Stem Cell Exosomes for the Treatment of COVID-19 Positive Patients With Acute Respiratory Distress Syndrome and/or Novel Coronavirus Pneumonia), which is not on this map. Cited by 56 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04798716 phase1 / phase2unknown statusnot on this mapstarted 2023, after this paper: background citation

Mesenchymal Stem Cell Exosomes for the Treatment of COVID-19 Positive Patients With Acute Respiratory Distress Syndrome and/or Novel Coronavirus Pneumonia

TypeinterventionalSponsorAVEM HealthCareRan2023 to 2024Enrolled55ConditionsCovid19, Novel Coronavirus Pneumonia, Acute Respiratory Distress SyndromeArmsMSC-exosomes delivered intravenously every other day on an escalating dose: (2:4:8), MSC-exosomes delivered intravenously every other day on an escalating dose (8:4:8), MSC-exosomes delivered intravenously every other day (8:8:8)
3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  18. Mesenchymal Stromal Cell Therapy in Lung Transplantation.Bioengineering (Basel, Switzerland) · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Airan LiuDepartment of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Xiwen ZhangDepartment of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Hongli HeDepartments of Anesthesiology and Cardiovascular Research Institute, University of California, San Francisco, CA, USA.
Li ZhouDepartments of Anesthesiology and Cardiovascular Research Institute, University of California, San Francisco, CA, USA.
Yoshifumi NaitoDepartments of Anesthesiology and Cardiovascular Research Institute, University of California, San Francisco, CA, USA.
Shinji SugitaDepartments of Anesthesiology and Cardiovascular Research Institute, University of California, San Francisco, CA, USA.
Jae-Woo LeeDepartments of Anesthesiology and Cardiovascular Research Institute, University of California, San Francisco, CA, USA.

Funding

Human Mesenchymal Stem Cell Microvesicles for the Treatment of Acute Lung InjuryR01HL113022 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, JAE WOO · 2012 to 2020
$4.1M
NHLBI NIH HHS R01 HL113022
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Acute Lung InjuryAnimalsCulture Media, ConditionedExtracellular VesiclesHumansMesenchymal Stem CellsMesenchymal Stem Cell TransplantationRespiratory Distress SyndromeCulture Media, ConditionedAcute lung injuryacute respiratory distress syndromeexosomesextracellular vesiclesmesenchymal stem or stromal cellsmicrovesicles

Identifiers

PMID31701782
PMCPMC6981051

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.