ArticleInternational ophthalmology2020
The use of in vivo confocal microscopy to track treatment success in fungal keratitis and to differentiate between Fusarium and Aspergillus keratitis.
Article in International ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Beyond the surface: a comprehensive review of corneal endotheliitis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- Article
- Nested PCR as a superior diagnostic method for Acanthamoeba keratitis compared to conventional techniques.Scientific reports · 2026Article
- Effective automatic classification methods via deep learning for multi-type infectious keratitis diagnosis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- In Vivo Confocal Microscopy and Anterior Segment Optical Coherence Tomography in Optimizing Diagnosis and Therapeutic Management in Fungal Keratitis: Case Reports and Literature Review.Journal of clinical medicine · 2025Article
- Clinical features, microbiological characteristics, and treatment outcomes of fungal keratitis in a tertiary referral hospital in Eastern China.BMC infectious diseases · 2025Article
- Infectious keratitis following photorefractive keratectomy: a 13-year study at a tertiary center.Journal of ophthalmic inflammation and infection · 2025Article
- Clinical Characteristics and In Vivo Confocal Microscopic Study in Candida Keratitis.Translational vision science & technology · 2025Article
- Infectious keratitis in pediatric population aged less than two years: a tertiary eye institute experience.Journal of ophthalmic inflammation and infection · 2024Article
- Microbial keratitis in the subtropical region of Korea: a comprehensive 12-year retrospective review at a single referral center.BMJ open · 2024Article
- From Clinical Suspicion to Diagnosis: A Review of Diagnostic Approaches and Challenges in Fungal Keratitis.Journal of clinical medicine · 2024Review
- Corneal subepithelial nerve fibers in type 2 diabetes: potential biomarker of diabetic neuropathy.International journal of ophthalmology · 2024Article
- Artificial Intelligence and Infectious Keratitis: Where Are We Now?Life (Basel, Switzerland) · 2023Review
- Rapid Point-of-Care Identification of Aspergillus Species in Microbial Keratitis.JAMA ophthalmology · 2023Article
- Post-laser refractive surgery keratitis: A concise narrative review.The Journal of international medical research · 2023Review
- Evaluation of the Autof ms1000 mass spectrometry for rapid clinical identification of filamentous fungi.BMC microbiology · 2023Article
- Modern Technologies in Diagnosis of Fungal Keratitis (Review).Sovremennye tekhnologii v meditsine · 2023Review
- Isorhamnetin Ameliorates Aspergillus fumigatus Keratitis by Reducing Fungal Load, Inhibiting Pattern-Recognition Receptors and Inflammatory Cytokines.Investigative ophthalmology & visual science · 2021Article
- Fungal keratitis: Mechanisms of infection and management strategies.Survey of ophthalmologyReview
- Anterior segment optical coherence tomography: a tool for infectious keratitis.Therapeutic advances in ophthalmologyReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the usefulness of serial in vivo confocal microscopy (IVCM) examinations to measure hyphal density for monitoring the treatment success among patients with fungal keratitis, and to compare the hyphal diameter as well as branching angle as a way of differentiation between Aspergillus and Fusarium species observed in IVCM. STUDY
designProspective nonrandomized study. PATIENTS AND
methodsThe study was conducted from February 2015 to September 2016. Hyphal diameter, density and branching angle measurements were performed using IVCM at admission and on a weekly basis for at least 2 weeks after the start of treatment.
resultsDuring the period of study, 65 patients with culture-confirmed fungal keratitis were recruited. Of them, 40 were culture-positive for Fusarium spp. and 25 patients for Aspergillus spp. Before the start of treatment, the mean branching angle did not differ between the two species and the mean hyphal diameter was statistically higher for Aspergillus spp. (p = 0.029). Two weeks after the start of treatment, the mean hyphal diameter was statistically lower (p < 0.001) in the treatment failure group. Also the hyphal density significantly decreased with successful treatment (p < 0.05).
conclusionDecreasing hyphal density in serial IVCMs might be used as an indicator to predict the successful response of fungal ulcers to treatment. Branching angle is not different between Aspergillus and Fusarium keratitis. The mean hyphal diameter is significantly lower in the treatment failure group.
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