Evidence map›Paper›PMID 31701153›Full record

Trial reportNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2020

Very Low Nicotine Content Cigarettes Disrupt the Feedback Loop of Affective States and Smoking Behavior.

Jason D Robinson, George Kypriotakis, Mustafa Al'absi, Rachel L Denlinger-Apte, David J Drobes, Scott J Leischow, F Joseph McClernon, Lauren R Pacek, Herbert H Severson, Tracy T Smith and 6 more

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Reducing Misperceptions About Very Low Nicotine Content Cigarettes: Insights From Adults Who Smoke.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 1 country.

Jason D RobinsonDepartment of Behavioral Science, University of Texas MD Anderson Cancer Center, Houston, TX.
George KypriotakisDepartment of Behavioral Science, University of Texas MD Anderson Cancer Center, Houston, TX.
Mustafa Al'absiDepartment of Family Medicine and BioBehavioral Health, University of Minnesota Medical School, Duluth, MN.
Rachel L Denlinger-ApteDepartment of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI.
David J DrobesDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL.
Scott J LeischowCollege of Health Solutions, Arizona State University, Phoenix, AZ.
F Joseph McClernonDepartment of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC.
Lauren R PacekDepartment of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC.
Herbert H SeversonOregon Research Institute, Eugene, OR.
Tracy T SmithPsychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC.
Eric C DonnyDepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC.
Xianghua LuoCancer Prevention and Control, Masonic Cancer Center, University of Minnesota, Minneapolis, MN.
Joni A JensenCancer Prevention and Control, Masonic Cancer Center, University of Minnesota, Minneapolis, MN.
Lori G StrayerCancer Prevention and Control, Masonic Cancer Center, University of Minnesota, Minneapolis, MN.
Paul M CinciripiniDepartment of Behavioral Science, University of Texas MD Anderson Cancer Center, Houston, TX.
Dorothy K HatsukamiCancer Prevention and Control, Masonic Cancer Center, University of Minnesota, Minneapolis, MN.
University of Minnesota · USThe University of Texas MD Anderson Cancer Center · USDuke University · USArizona State University · USBrown University · USMedical University of South Carolina · USMoffitt Cancer Center · USOregon Research Institute · USWake Forest University · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8M
Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Timothy C. Hallstrom · 1998 to 2026
$100.4M
VERY LOW NICOTINE CIGARETTES IN SMOKERS WITH SCHIZOPHRENIAU54DA031659 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HECHT, STEPHEN S · 2011 to 2022
$64.7M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
Stress, Appetite, and Smoking RelapseR01DA027232 · NIDA · UNIVERSITY OF MINNESOTA · PI AL'ABSI, MUSTAFA, LEE, DUSTIN CLARK · 2010 to 2025
$4.6M
NCATS NIH HHS UL1 TR000114NCATS NIH HHS UL1 TR002494NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA077598NIDA NIH HHS R01 DA027232NIDA NIH HHS U54 DA031659
6 · The paper itself

Abstract

introductionSmoking to reduce negative affect has been identified as a key motivational feature of tobacco use. Our recent work suggests that smoking very low nicotine content (VLNC) cigarettes reduces the relationship between negative affect and smoking behavior over a 6-week period. Here, we sought to extend our findings by evaluating whether a gradual or immediate approach to switching to VLNC cigarettes led to a differential reduction in the relationship between affect and smoking behavior over a longer (20-week) period. AIMS AND

methodsParticipants (n = 1250) were adult smokers from 10 US sites randomized to one of three groups: gradual nicotine reduction (15.5, 11.7, 5.2, 2.4, and 0.4 mg of nicotine per gram of tobacco [mg/g]), immediate nicotine reduction (0.4 mg/g), or standard nicotine content cigarettes (15.5 mg/g; control), for 20 weeks. We examined whether the relationship between affect-both negative and positive-and cigarettes per day differed as a function of reduction group.

resultsWe found that both negative and positive affect were associated with cigarette consumption in the control group, but not in the gradual or immediate reduction groups across the 20 weeks of exposure.

conclusionsOur results extend previous findings that switching to VLNC cigarettes disrupts the relationship between affect and cigarette consumption by showing that either gradually or immediately reducing cigarette nicotine content achieves this disruption. These findings provide further evidence that switching to VLNC cigarettes reduces nicotine-related reinforcement of cigarette smoking. IMPLICATIONS: These findings support the notion that switching to very low nicotine content cigarettes reduces the association between affect and smoking behavior, and that either a gradual or immediate nicotine reduction approach achieves this reduction. This provides further evidence that switching to very low nicotine content cigarettes weakens reinforcement mechanisms associated with nicotine dependence.

Indexed as

FeedbackReinforcement, PsychologyAdolescentAdultCase-Control StudiesCigarette SmokingDouble-Blind MethodEmotionsFemaleHumansMaleMotivationNicotineSmokersSmokingSmoking CessationNicotine

Identifiers

PMID31701153
PMCPMC7364840
OpenAlexW2983339204

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.