ArticleJournal of experimental botany2020
A role for Arabidopsis growth-regulating factors 1 and 3 in growth-stress antagonism.
Article in Journal of experimental botany, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 58 citations in OpenAlex.
- SOT2/Growth-Regulating Factor 3 Modulates Salt Tolerance by Regulating Gibberellin-DELLA Signalling.Plant, cell & environment · 2026Article
- The E3 ubiquitin ligase RHB1A and the transcription factor GRF1 form a regulatory module that orchestrates the trade-off between photosynthetic growth and salt tolerance in poplar.Plant communications · 2026Article
- Analysis of the TGA gene family and the role of SlTGA03 in tomato resistance to Meloidogyne enterolobii.BMC genomics · 2026Article
- Comprehensive Investigation of GRF Transcription Factors and Associated Responses to Drought Stress in Oat (Plants (Basel, Switzerland) · 2026Article
- Rewiring of LEUNIG_HOMOLOG interaction networks marks regulatory shifts from meristem to organ growth in Arabidopsis flowers.The Plant journal : for cell and molecular biology · 2025Article
- An elite RNA-DEPENDENT RNA POLYMERASE3 allele enhances preharvest sprouting resistance in rice.Plant physiology · 2025Article
- Hormonal and Transcriptomic Insights into Inflorescence Stalk Elongation in Oil Palm.Plants (Basel, Switzerland) · 2025Article
- The WRC domain of GRF transcription factors: Structure and DNA recognition.Protein science : a publication of the Protein Society · 2025Article
- Genome-wide characterization of GRF-GIF transcriptional modules in kenaf (Hibiscus cannabinus L.) reveals their roles in plant development and multi-stress adaptation.Functional & integrative genomics · 2025Article
- The genome of Haberlea rhodopensis provides insights into the mechanisms for tolerance to multiple extreme environments.Cellular and molecular life sciences : CMLS · 2024Article
- Genome-wide molecular evolution analysis of the GRF and GIF gene families in Plantae (Archaeplastida).BMC genomics · 2024Article
- Physiological and molecular response mechanisms of tomato seedlings to cadmium (Cd) and lead (Pb) stress.PeerJ · 2024Article
- Growing Conditions and Varietal Ecologies Differently Regulates the Growth-regulating-factor (GRFs) Gene Family in Rice.Iranian journal of biotechnology · 2024Article
- BpGRP1 acts downstream of BpmiR396c/BpGRF3 to confer salt tolerance in Betula platyphylla.Plant biotechnology journal · 2024Article
- Conceptual Framework of Epigenetic Analyses of Plant Responses to Sedentary Endoparasitic Nematodes.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Comparatively Evolution and Expression Analysis of GRF Transcription Factor Genes in Seven Plant Species.Plants (Basel, Switzerland) · 2023Article
- Chromosome-scale assemblies of the male and female Populus euphratica genomes reveal the molecular basis of sex determination and sexual dimorphism.Communications biology · 2022Article
- Charged Gold Nanoparticles Promote In Vitro Proliferation inAntioxidants (Basel, Switzerland) · 2022Article
- Application of 2,4-Epibrassinolide Improves Drought Tolerance in Tobacco through Physiological and Biochemical Mechanisms.Biology · 2022Article
- miR778 mediates gene expression, histone modification, and DNA methylation during cyst nematode parasitism.Plant physiology · 2022Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growth-regulating factors (GRFs) belong to a small family of transcription factors that are highly conserved in plants. GRFs regulate many developmental processes and plant responses to biotic and abiotic stimuli. Despite the importance of GRFs, a detailed mechanistic understanding of their regulatory functions is still lacking. In this study, we used ChIP sequencing (ChIP-seq) to identify genome-wide binding sites of Arabidopsis GRF1 and GRF3, and correspondingly their direct downstream target genes. RNA-sequencing (RNA-seq) analysis revealed that GRF1 and GRF3 regulate the expression of a significant number of the identified direct targets. The target genes unveiled broad regulatory functions of GRF1 and GRF3 in plant growth and development, phytohormone biosynthesis and signaling, and the cell cycle. Our analyses also revealed that clock core genes and genes with stress- and defense-related functions are most predominant among the GRF1- and GRF3-bound targets, providing insights into a possible role for these transcription factors in mediating growth-defense antagonism and integrating environmental stimuli into developmental programs. Additionally, GRF1 and GRF3 target molecular nodes of growth-defense antagonism and modulate the levels of defense- and development-related hormones in opposite directions. Taken together, our results point to GRF1 and GRF3 as potential key determinants of plant fitness under stress conditions.
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