Evidence map›Paper›PMID 31701144›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020

Clinic-Level Factors Associated With Time to Antiretroviral Initiation and Viral Suppression in a Large, Urban Cohort.

Anne K Monroe, Lindsey P Happ, Nabil Rayeed, Yan Ma, Maria J Jaurretche, Arpi S Terzian, Kevin Trac, Michael A Horberg, Alan E Greenberg, Amanda D Castel

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anne K MonroeDepartment of Epidemiology, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA.
Lindsey P HappDepartment of Epidemiology, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA.
Nabil RayeedCerner Corporation, Kansas City, Missouri, USA.
Yan MaDepartment of Biostatistics, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA.
Maria J JaurretcheDepartment of Epidemiology, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA.
Arpi S TerzianDepartment of Epidemiology, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA.
Kevin TracDepartment of Epidemiology, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA.
Michael A HorbergMid-Atlantic Permanente Research Institute, Kaiser Permanente Mid-Atlantic States, Rockville, Maryland, USA.
Alan E GreenbergDepartment of Epidemiology, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA.
Amanda D CastelDepartment of Epidemiology, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA.

Funding

Terry Beirn CPCRA Clinical Trials UnitUM1AI069503 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI KAN, VIRGINIA · 2012 to 2020
$38.5M
CPCRA Clinical Trials UnitU01AI069503 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI GORDIN, FRED M · 2007 to 2011
$33.9M
Data Driven Methods for Missing Data Imputation in Surgical Disparities ResearchR01MD013901 · NIMHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MA, YAN · 2019 to 2022
$996k
NIAID NIH HHS U01 AI069503NIAID NIH HHS UM1 AI069503NIMHD NIH HHS R01 MD013901
6 · The paper itself

Abstract

backgroundUsing the results of a site assessment survey performed at clinics throughout Washington, DC, we studied the impact of clinic-level factors on antiretroviral therapy (ART) initiation and viral suppression (VS) among people living with human immunodeficiency virus (HIV; PLWH).

methodsThis was a retrospective analysis from the District of Columbia (DC) Cohort, an observational, clinical cohort of PLWH from 2011-2018. We included data from PLWH not on ART and not virally suppressed at enrollment. Outcomes were ART initiation and VS (HIV RNA < 200 copies/mL). A clinic survey captured information on care delivery (eg, clinical services, adherence services, patient monitoring services) and clinic characteristics (eg, types of providers, availability of evenings/weekends sessions). Multivariate marginal Cox regression models were generated to identify those factors associated with the time to ART initiation and VS.

resultsMultiple clinic-level factors were associated with ART initiation, including retention in care monitoring and medication dispensing reviews (adjusted hazard ratios [aHRs], 1.34 to 1.40; P values < .05 for both). Furthermore, multiple factors were associated with VS, including retention in HIV care monitoring, medication dispensing reviews, and the presence of a peer interventionist (aHRs, 1.35 to 1.72; P values < .05 for all). In multivariable models evaluating different combinations of clinic-level factors, enhanced adherence services (aHR, 1.37; 95% confidence interval [CI], 1.18-1.58), medication dispensing reviews (aHR, 1.22; 95% CI, 1.10-1.36), and the availability of opioid treatment (aHR, 1.26; 95% CI, 1.01-1.57) were all associated with the time to VS.

conclusionsThe observed association between clinic-level factors and ART initiation/VS suggests that the presence of specific clinic services may facilitate the achievement of HIV treatment goals.

Indexed as

Anti-HIV AgentsHIV InfectionsAnti-Retroviral AgentsCohort StudiesDistrict of ColumbiaHumansRetrospective StudiesViral LoadAnti-HIV AgentsAnti-Retroviral Agentsantiretroviral therapyHIVHIV care continuumviral suppression

Identifiers

PMID31701144
PMCPMC7583410

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.