ArticleCerebral cortex (New York, N.Y. : 1991)2020
Dissociable Mechanisms of Verbal Working Memory Revealed through Multivariate Lesion Mapping.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Convergence of heteromodal lexical retrieval in the lateral prefrontal cortex.Scientific reports · 2021Trial
- Tumor-conditioned inter-patient registration using planning computed tomography for voxel-based analysis to predict radiation pneumonitis in lung cancer patients.Physics and imaging in radiation oncology · 2026Article
- Non-Verbal Working Memory in Post-Stroke Motor Aphasia: A Pilot Study Using the Tactual Span.Neurology international · 2025Article
- Is working memory domain-general or domain-specific?Trends in cognitive sciences · 2024Review
- Cognitive impairment in children and adolescents living with perinatal HIV disease in the ART era: a meta-analysis.EClinicalMedicine · 2024Article
- Lesion mapping in neuropsychological research: A practical and conceptual guide.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Spatial normalization for voxel-based lesion symptom mapping: impact of registration approaches.Frontiers in neuroscience · 2024Article
- Listening to Yourself and Watching Your Tongue: Distinct Abilities and Brain Regions for Monitoring Semantic and Phonological Speech Errors.Journal of cognitive neuroscience · 2023Article
- Cognitive neuroscience perspective on memory: overview and summary.Frontiers in human neuroscience · 2023Article
- The neural coding of tonal working memory load: An functional magnetic resonance imaging study.Frontiers in neuroscience · 2022Article
- Long-interval intracortical inhibition in primary motor cortex related to working memory in middle-aged adults.Frontiers in psychology · 2022Article
- Naturalistic Language Input is Associated with Resting-State Functional Connectivity in Infancy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Lesions that do or do not impair digit span: a study of 816 stroke survivors.Brain communications · 2021Article
- Working Memory Capacities Neurally Dissociate: Evidence from Acute Stroke.Cerebral cortex communications · 2021Article
- Brain structures and cognitive abilities important for the self-monitoring of speech errors.Neurobiology of language (Cambridge, Mass.) · 2020Article
- Lesion-Based Disconnectome Explains Cognitive Outcomes in Multiple Sclerosis.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
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Authors and funding
6 authors.
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Abstract
Two maintenance mechanisms with separate neural systems have been suggested for verbal working memory: articulatory-rehearsal and non-articulatory maintenance. Although lesion data would be key to understanding the essential neural substrates of these systems, there is little evidence from lesion studies that the two proposed mechanisms crucially rely on different neuroanatomical substrates. We examined 39 healthy adults and 71 individuals with chronic left-hemisphere stroke to determine if verbal working memory tasks with varying demands would rely on dissociable brain structures. Multivariate lesion-symptom mapping was used to identify the brain regions involved in each task, controlling for spatial working memory scores. Maintenance of verbal information relied on distinct brain regions depending on task demands: sensorimotor cortex under higher demands and superior temporal gyrus (STG) under lower demands. Inferior parietal cortex and posterior STG were involved under both low and high demands. These results suggest that maintenance of auditory information preferentially relies on auditory-phonological storage in the STG via a nonarticulatory maintenance when demands are low. Under higher demands, sensorimotor regions are crucial for the articulatory rehearsal process, which reduces the reliance on STG for maintenance. Lesions to either of these regions impair maintenance of verbal information preferentially under the appropriate task conditions.
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