Evidence map›Paper›PMID 31701117›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2020

Functional Territories of Human Dentate Nucleus.

Xavier Guell, Anila M D'Mello, Nicholas A Hubbard, Rachel R Romeo, John D E Gabrieli, Susan Whitfield-Gabrieli, Jeremy D Schmahmann, Sheeba Arnold Anteraper

Open access · bronzeAbstract read
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 80 citations in OpenAlex.

  1. Review
  2. The Cerebellar Connectome.Cerebellum (London, England) · 2026
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  8. Pontine Functional Connectivity Gradients.Cerebellum (London, England) · 2025
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Xavier GuellMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Anila M D'MelloMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Nicholas A HubbardMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Rachel R RomeoMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
John D E GabrieliMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Susan Whitfield-GabrieliMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Jeremy D SchmahmannAtaxia Unit, Cognitive Behavioral Neurology Unit, Laboratory for Neuroanatomy and Cerebellar Neurobiology, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Sheeba Arnold AnteraperMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Massachusetts Institute of Technology · USBoston Children's Hospital · USHarvard University · USMcGovern Institute for Brain Research · USNortheastern University · USUniversity of Nebraska–Lincoln · US

Funding

Supplementary funding for U01NS104326 Clinical Trial Readiness for SCA1 and SCA3 (“READISCA”)U01NS104326 · NINDS · METHODIST HOSPITAL RESEARCH INSTITUTE · PI ASHIZAWA, TETSUO, DURR, ALEXANDRA · 2018 to 2022
$6.1M
TRAINING PROGRAM IN BEHAVIORAL/COGNITIVE NEUROSCIENCET32MH017168 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI KABLE, JOSEPH W · 1985 to 2018
$4.2M
Partnership for Magnetic Resonance Spectroscopy Biomarker Development-SupplementR01NS080816 · NINDS · UNIVERSITY OF MINNESOTA · PI OZ, GULIN · 2015 to 2019
$3.2M
Translational Post-doctoral Training in NeurodevelopmentT32MH112510 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI DAVID C GLAHN, CHARLES Alexander NELSON · 2017 to 2026
$2.6M
Characterizing Neural Adaptation in Autism Spectrum DisorderF32MH117933 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI DMELLO, ANILA · 2018 to 2022
$222k
Adolescent Brain Bases of Intergenerational Risk for DepressionF32MH114525 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HUBBARD, NICHOLAS · 2017 to 2019
$123k
Effects of linguistic input on the neural capacity for language developmentF31HD086957 · NICHD · HARVARD MEDICAL SCHOOL · PI ROMEO, RACHEL RENE · 2016 to 2017
$55k
NICHD NIH HHS F31 HD086957NIMH NIH HHS F32 MH114525NIMH NIH HHS T32 MH017168NIMH NIH HHS T32 MH112510NINDS NIH HHS R01 NS080816NINDS NIH HHS U01 NS104326
6 · The paper itself

Abstract

Anatomical connections link the cerebellar cortex with multiple sensory, motor, association, and paralimbic cerebral areas. The majority of fibers that exit cerebellar cortex synapse in dentate nuclei (DN) before reaching extracerebellar structures such as cerebral cortex, but the functional neuroanatomy of human DN remains largely unmapped. Neuroimaging research has redefined broad categories of functional division in the human brain showing that primary processing, attentional (task positive) processing, and default-mode (task negative) processing are three central poles of neural macroscale functional organization. This broad spectrum of human neural processing categories is represented not only in the cerebral cortex, but also in the thalamus, striatum, and cerebellar cortex. Whether functional organization in DN obeys a similar set of macroscale divisions, and whether DN are yet another compartment of representation of a broad spectrum of human neural processing categories, remains unknown. Here, we show for the first time that human DN are optimally divided into three functional territories as indexed by high spatio-temporal resolution resting-state MRI in 77 healthy humans, and that these three distinct territories contribute uniquely to default-mode, salience-motor, and visual cerebral cortical networks. Our findings provide a systems neuroscience substrate for cerebellar output to influence multiple broad categories of neural control.

Indexed as

AdolescentAdultCerebellar NucleiCerebral CortexChildFemaleHumansMagnetic Resonance ImagingMaleNerve Netcerebellumdefault mode networkfMRIfunctional gradientssalience network

Identifiers

PMID31701117
PMCPMC7175000
OpenAlexW2986184209

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.