ArticleLab on a chip2020
micrIO: an open-source autosampler and fraction collector for automated microfluidic input-output.
Article in Lab on a chip, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Quantifying protein unfolding kinetics with a high-throughput microfluidic platform.Cell systems · 2026Article
- Automated synthetic cell-based screening for designed proteins with emergent functions.Nature communications · 2026Article
- Large field of view fluorescence imaging of microfluidic devices with a tandem-lens macroscope.Lab on a chip · 2026Article
- Open-source robotic chip-to-plate interface for high-throughput microfluidic generation of materials libraries.bioRxiv : the preprint server for biology · 2026Article
- Large field of view fluorescence imaging of microfluidic devices with a tandem-lens macroscopebioRxiv : the preprint server for biology · 2025Article
- Artificial Intelligence-Empowered Automated Double Emulsion Droplet Library Generation.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Article
- Low-cost modular chromatography column rack and vial holders.HardwareX · 2023Article
- Biomolecular condensate phase diagrams with a combinatorial microdroplet platform.Nature communications · 2022Article
- Open-source personal pipetting robots with live-cell incubation and microscopy compatibility.Nature communications · 2022Article
- MRBLE-pep Measurements Reveal Accurate Binding Affinities for B56, a PP2A Regulatory Subunit.ACS measurement science au · 2021Article
- Miau, a microbalance autosampler.HardwareX · 2021Article
- Article
- Comparison of Design Approaches for Low-Cost Sampling Mechanisms in Open-Source Chemical Instrumentation.HardwareX · 2021Article
- DIY Universal Fraction Collector.Analytical chemistry · 2021Article
- Article
- High diversity droplet microfluidic libraries generated with a commercial liquid spotter.Scientific reports · 2021Article
- Low-cost and open-source strategies for chemical separations.Journal of chromatography. A · 2021Review
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Microfluidic devices are an enabling technology for many labs, facilitating a wide range of applications spanning high-throughput encapsulation, molecular separations, and long-term cell culture. In many cases, however, their utility is limited by a 'world-to-chip' barrier that makes it difficult to serially interface samples with these devices. As a result, many researchers are forced to rely on low-throughput, manual approaches for managing device input and output (IO) of samples, reagents, and effluent. Here, we present a hardware-software platform for automated microfluidic IO (micrIO). The platform, which is uniquely compatible with positive-pressure microfluidics, comprises an 'AutoSipper' for input and a 'Fraction Collector' for output. To facilitate widespread adoption, both are open-source builds constructed from components that are readily purchased online or fabricated from included design files. The software control library, written in Python, allows the platform to be integrated with existing experimental setups and to coordinate IO with other functions such as valve actuation and assay imaging. We demonstrate these capabilities by coupling both the AutoSipper and Fraction Collector to two microfluidic devices: a simple, valved inlet manifold and a microfluidic droplet generator that produces beads with distinct spectral codes. Analysis of the collected materials in each case establishes the ability of the platform to draw from and output to specific wells of multiwell plates with negligible cross-contamination between samples.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.