Evidence map›Paper›PMID 31701070›Full record

ArticleHepatology communications2019

Mortality Related to Nonalcoholic Fatty Liver Disease Is Increasing in the United States.

James M Paik, Linda Henry, Leyla De Avila, Elena Younossi, Andrei Racila, Zobair M Younossi

Open access · goldAbstract read
In one paragraph

Article in Hepatology communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 2 pooled it
16.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 2 syntheses or guidelines pooled it, 230 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Menopause May Partially Explain Age-Related Increased Risk of MASLD Fibrosis: A Causal Mediation Analysis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026
    Article
  7. Review
  8. Observational
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. The menopause-obesity axis in MASH progression: from estrogen decline to liver fibrosis.Frontiers in gastroenterology (Lausanne, Switzerland) · 2026
    Review
  15. Article
  16. Article
  17. Review
  18. Autoantibodies are associated with worse outcomes in MASLD.JHEP reports : innovation in hepatology · 2025
    Article
  19. Article
  20. Article

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

James M PaikBetty and Guy Beatty Center for Integrated Research Inova Health System Falls Church VA.
Linda HenryCenter for Outcomes Research in Liver Diseases Washington DC.
Leyla De AvilaBetty and Guy Beatty Center for Integrated Research Inova Health System Falls Church VA.
Elena YounossiBetty and Guy Beatty Center for Integrated Research Inova Health System Falls Church VA.
Andrei RacilaBetty and Guy Beatty Center for Integrated Research Inova Health System Falls Church VA.
Zobair M YounossiBetty and Guy Beatty Center for Integrated Research Inova Health System Falls Church VA.ORCID https://orcid.org/0000-0001-9313-577X
Inova Health System · USCenter for Outcomes Research in Liver Diseases · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Population-level nonalcoholic fatty liver disease (NAFLD) death rate data are sparse. We described death rates for adults with NAFLD in the United States using mortality data from the National Vital Statistics System multiple-cause mortality data (2007-2016). Decedents who had NAFLD were identified by International Classification of Diseases (ICD) codes K75.81, K76.0, K74.0, K74.6, and K76.9. Among NAFLD decedents, cause-specific deaths (e.g., cardiovascular disease [CVD], cirrhosis, hepatocellular carcinoma [HCC], non-liver cancer, diabetes mellitus [DM]) were identified by underlying cause of death ICD-10 codes. Trends were evaluated by average annual percentage change (AAPC) in age-standardized death rate (ASDR) per 100,000 persons. Among the 25,129,960 decedents aged ≥20 years, 353,234 (1.4%) decedents had NAFLD (212,322 men; 260,765 non-Hispanic whites, 32,868 non-Hispanic blacks, 46,530 Hispanics, 5,025 non-Hispanic American Indian or Alaska Natives [AIANs], 7,023 non-Hispanic Asian or Pacific Islanders [APIs]), with a mean age at death of 64.47 ± 13.17 years. During the study period, the ASDR for NAFLD increased by 15% (12.94 to 14.90; AAPC, 1.98%;

Identifiers

PMID31701070
PMCPMC6824058
OpenAlexW2968982492

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.