ArticleCommunications biology2019
A natural mouse model reveals genetic determinants of systemic capillary leak syndrome (Clarkson disease).
Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Monoclonal gammopathy of clinical significance: a multisystem review.Blood cancer journal · 2026Review
- Proteomic signature of HIV-associated subclinical left atrial remodeling and incident heart failure.Nature communications · 2025Article
- Article
- Systemic capillary leak syndrome.Nature reviews. Disease primers · 2024Review
- Hypersensitive blood vessels in Clarkson disease.The Journal of clinical investigation · 2024Article
- Intrinsic endothelial hyperresponsiveness to inflammatory mediators drives acute episodes in models of Clarkson disease.The Journal of clinical investigation · 2024Article
- A ligand-independent Tie2-activating antibody reduces vascular leakage in models of Clarkson disease.Science advances · 2023Article
- A genetic locus complements resistance to Bordetella pertussis-induced histamine sensitization.Communications biology · 2023Article
- Identification and validation of six acute myocardial infarction-associated variants, including a novel prognostic marker for cardiac mortality.Frontiers in cardiovascular medicine · 2023Article
- Fatal Exacerbations of Systemic Capillary Leak Syndrome Complicating Coronavirus Disease.Emerging infectious diseases · 2021Review
- Network-Based Functional Prediction Augments Genetic Association To Predict Candidate Genes for Histamine Hypersensitivity in Mice.G3 (Bethesda, Md.) · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
The systemic capillary leak syndrome (SCLS, Clarkson disease) is a disorder of unknown etiology characterized by recurrent episodes of vascular leakage of proteins and fluids into peripheral tissues, resulting in whole-body edema and hypotensive shock. The pathologic mechanisms and genetic basis for SCLS remain elusive. Here we identify an inbred mouse strain, SJL, which recapitulates cardinal features of SCLS, including susceptibility to histamine- and infection-triggered vascular leak. We named this trait "Histamine hypersensitivity" (Hhs/
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.