Evidence map›Paper›PMID 31700881›Full record

ArticleAnnals of translational medicine2019

Urinary levels of podocyte-derived microparticles are associated with the progression of chronic kidney disease.

Jian Lu, Ze-Bo Hu, Pei-Pei Chen, Chen-Chen Lu, Jia-Xiu Zhang, Xue-Qi Li, Ben-Yin Yuan, Si-Jia Huang, Kun-Ling Ma

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jian LuInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.
Ze-Bo HuInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.
Pei-Pei ChenInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.
Chen-Chen LuInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.
Jia-Xiu ZhangInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.
Xue-Qi LiInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.
Ben-Yin YuanInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.
Si-Jia HuangInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.
Kun-Ling MaInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.
Zhongda Hospital Southeast University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPodocyte-derived microparticles (MPs) could be secreted from activated or apoptotic podocytes. An increased number of podocyte-derived MPs in the urine might reflect podocyte injury in renal diseases. This study aimed to observe the change of urinary podocyte-derived MP levels in patients with chronic kidney disease (CKD) and to further explore its correlation with the progression of CKD.

methodsA prospective, longitudinal study was conducted in eighty patients with biopsy-proven CKD. Podocyte-derived MPs (annexin V and podocalyxin positive) were detected by flow cytometry. The number of urinary podocyte-derived MPs was analyzed to evaluate the association with biochemical measurements and pathological glomerulosclerosis assessment. Patients with idiopathic membranous nephropathy (IMN) were followed up after the six-month treatment of prednisone combined with tacrolimus to evaluate the association of urinary podocyte-derived MP levels and the remission of IMN.

resultsThe CKD patients had higher urinary podocyte-derived MP levels compared with healthy controls (HCs). Baseline urinary levels of podocyte-derived MPs were positively correlated with 24-hour proteinuria, while were inversely correlated with the percentage of global glomerulosclerosis. The urinary podocyte-derived MPs levels had good discrimination for glomerulosclerosis [area under curve (AUC), 0.66]. The urinary podocyte-derived MPs levels in IMN patients were significantly decreased accompanied with the recovery of abnormal clinical parameters after six-month treatment.

conclusionsThe urinary levels of podocyte-derived MPs were closely associated with podocyte injury and glomerulosclerosis, which could be useful for monitoring disease activity in CKD patients. Urinary podocyte-derived MPs might be a non-invasive biomarker for the evaluation of early CKD progression.

Indexed as

chronic kidney disease (CKD)Podocyte-derived microparticle (podocyte-derived MP)podocyte injury

Identifiers

PMID31700881
PMCPMC6803175
OpenAlexW2974663243

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.