Evidence map›Paper›PMID 31700870›Full record

ArticleAnnals of translational medicine2019

Fine mapping of thyroglobulin gene identifies two independent risk loci for Graves' disease in Chinese Han population.

Miao Xuan, Shuang-Xia Zhao, Chen-Yan Yan, Jun Yang, Ying Li, Li-Ge Song, Huai-Dong Song, Xiu-Zhen Zhang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Miao XuanDepartment of Endocrinology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
Shuang-Xia ZhaoThe Core Laboratory in Medical Center of Clinical Research, Department of Endocrinology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University (SJTU) School of Medicine, Shanghai 200011, China.
Chen-Yan YanThe Core Laboratory in Medical Center of Clinical Research, Department of Endocrinology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University (SJTU) School of Medicine, Shanghai 200011, China.
Jun YangDepartment of Clinical Skill Practice and Training Center, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
Ying LiDepartment of Endocrinology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
Li-Ge SongDepartment of Endocrinology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
Huai-Dong SongThe Core Laboratory in Medical Center of Clinical Research, Department of Endocrinology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University (SJTU) School of Medicine, Shanghai 200011, China.
Xiu-Zhen ZhangDepartment of Endocrinology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
Shanghai Ninth People's Hospital · CNTongji Hospital · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to determine independent risk loci of Graves' disease (GD) in the thyroglobulin (TG) region.

methodsIn this two-staged association study, a total of 9,757 patients with GD and 10,626 sex-matched controls were recruited from Chinese Han population. Illumina Human660-Quad BeadChips in the discovery stage and TaqMan SNP Genotyping Assays in the replication stage were used for genotyping. Trend test and logistic regression analysis were performed in this association study.

resultsIn the discovery stage, rs2294025 and rs7005834 were the most highly associated susceptibility loci with GD in

conclusionsThe fine mapping study of thyroglobulin identified two independent SNPs (rs2294025 and rs7005834) for GD susceptibility. However, no significant differences for rs2294025 and rs7005834 were observed, between the different clinical phenotypes of GD, including gender, Graves' ophthalmopathy (GO), and serum levels of thyrotropin receptor antibody, thyroid peroxidase antibody, and thyroglobulin antibody. These results provide a deeper understanding of the association mechanism of

Indexed as

Graves’ disease (GD)single nucleotide polymorphism (SNP)Thyroglobulin

Identifiers

PMID31700870
PMCPMC6803187
OpenAlexW2975114784

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.