ArticleMicrosystems & nanoengineering2019
Uniaxially crumpled graphene as a platform for guided myotube formation.
Article in Microsystems & nanoengineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Recent advances in electroactive biomaterials and electrical stimulation for skeletal muscle regeneration: materials, strategies, and mechanistic insights.Materials today. Bio · 2026Review
- Engineering multifunctional surface topography to regulate multiple biological responses.Biomaterials · 2025Review
- Nanotopographical Cues Tune the Therapeutic Potential of Extracellular Vesicles for the Treatment of Aged Skeletal Muscle Injuries.ACS nano · 2023Article
- Immunoglobulin adsorption and film formation on mechanically wrinkled and crumpled surfaces at submonolayer coverage.Nanoscale advances · 2023Article
- Effect of Boron-Doped Mesoporous Bioactive Glass Nanoparticles on C2C12 Cell Viability and Differentiation: Potential for Muscle Tissue Application.ACS biomaterials science & engineering · 2022Article
- Article
- An electroactive hybrid biointerface for enhancing neuronal differentiation and axonal outgrowth on bio-subretinal chip.Materials today. Bio · 2022Article
- 3D Printed Graphene-PLA Scaffolds Promote Cell Alignment and Differentiation.International journal of molecular sciences · 2022Article
- Redox Polymers for Tissue Engineering.Frontiers in medical technology · 2021Review
- Rapid nanomolding of nanotopography on flexible substrates to control muscle cell growth with enhanced maturation.Microsystems & nanoengineering · 2021Article
- Graphene Hybrid Materials for Controlling Cellular Microenvironments.Materials (Basel, Switzerland) · 2020Review
- Graphene oxide nanofilm and the addition of L-glutamine can promote development of embryonic muscle cells.Journal of nanobiotechnology · 2020Article
- Self-cleaning semiconductor heterojunction substrate: ultrasensitive detection and photocatalytic degradation of organic pollutants for environmental remediation.Microsystems & nanoengineering · 2020Article
- 3D Graphene Scaffolds for Skeletal Muscle Regeneration: Future Perspectives.Frontiers in bioengineering and biotechnology · 2020Review
- BioengineeredJournal of tissue engineeringReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Graphene, owing to its inherent chemical inertness, biocompatibility, and mechanical flexibility, has great potential in guiding cell behaviors such as adhesion and differentiation. However, due to the two-dimensional (2D) nature of graphene, the microfabrication of graphene into micro/nanoscale patterns has been widely adopted for guiding cellular assembly. In this study, we report crumpled graphene, i.e., monolithically defined graphene with a nanoscale wavy surface texture, as a tissue engineering platform that can efficiently promote aligned C2C12 mouse myoblast cell differentiation. We imparted out-of-plane, nanoscale crumpled morphologies to flat graphene via compressive strain-induced deformation. When C2C12 mouse myoblast cells were seeded on the uniaxially crumpled graphene, not only were the alignment and elongation promoted at a single-cell level but also the differentiation and maturation of myotubes were enhanced compared to that on flat graphene. These results demonstrate the utility of the crumpled graphene platform for tissue engineering and regenerative medicine for skeletal muscle tissues.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.