Evidence map›Paper›PMID 31700630›Full record

Observational studyUnited European gastroenterology journal2019

A multicentre prospective cohort study assessing the effectiveness of budesonide MMX® (Cortiment®

Silvio Danese, Ailsa Hart, Axel Dignass, Gionata Fiorino, Edouard Louis, Stefanos Bonovas, Geert D'Haens, Iris Dotan, Gerhard Rogler, Kristine Paridaens and 1 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in United European gastroenterology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02586259 (A Prospective Multi-centre Observational Cohort Study Assessing the Effectiveness of Cortiment® for the Treatment of Mild-to-moderate Active Ulcerative Colitis in Routine Clinical Practice), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02586259 completednot on this map

A Prospective Multi-centre Observational Cohort Study Assessing the Effectiveness of Cortiment® for the Treatment of Mild-to-moderate Active Ulcerative Colitis in Routine Clinical Practice

TypeobservationalSponsorFerring PharmaceuticalsRan2015 to 2018Enrolled378ConditionsUlcerative ColitisArmsbudesonide MMX®
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Choosing Therapies in Ulcerative Colitis.Journal of the Canadian Association of Gastroenterology · 2024
    Article
  5. Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Silvio DaneseIBD Centre Humanitas Clinical and Research Centre, Milan, Italy.
Ailsa HartSt Mark's Hospital, Harrow, UK.
Axel DignassDepartment of Medicine I, Agaplesion Markus Hospital, Goethe-University, Frankfurt, Germany.ORCID 0000-0002-9724-054X
Gionata FiorinoIBD Centre Humanitas Clinical and Research Centre, Milan, Italy.
Edouard LouisCHU de Liège, Liège, Belgium.
Stefanos BonovasIBD Centre Humanitas Clinical and Research Centre, Milan, Italy.ORCID 0000-0001-6102-6579
Geert D'HaensAmsterdam University Medical Centre, Amsterdam, the Netherlands.
Iris DotanDivision of Gastroenterology, Rabin Medical Center, Petah Tikva, and the Sackler Faculty of Medicine, Tel Aviv, Israel.
Gerhard RoglerDivision of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Kristine ParidaensFerring Pharmaceuticals, St Prex, Switzerland.
Laurent Peyrin-BirouletDepartment of Hepato-Gastroenterology and Inserm U954, University Hospital of Nancy, Lorraine University, Vandoeuvre-lès-Nancy, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cortiment® Methods: This was a multicentre observational prospective cohort study conducted in Europe and Canada. Effectiveness, safety, and tolerability of Cortiment® Results: Data from 326 patients with mild-to-moderate UC were analysed for the primary endpoint. Clinical benefit was achieved in 60.1% (196/326) of patients at the end of Cortiment® Conclusions: This was the first time that a large cohort study was conducted with Cortiment®

Indexed as

AdultAnti-Inflammatory Agents, Non-SteroidalBudesonideCohort StudiesColitis, UlcerativeDosage FormsDrug Therapy, CombinationFemaleGlucocorticoidsHumansMaleMesalamineMiddle AgedProspective StudiesSeverity of Illness IndexTreatment OutcomeAnti-Inflammatory Agents, Non-SteroidalBudesonideDosage FormsGlucocorticoidsMesalamine5-ASAbudesonideinflammatory bowel diseasemesalamineMMXUlcerative colitis

Identifiers

PMID31700630
PMCPMC6826527

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.