Evidence map›Paper›PMID 31700628›Full record

ReviewUnited European gastroenterology journal2019

Clinical management of autoimmune hepatitis.

Simon Pape, Christoph Schramm, Tom Jg Gevers

Open access · hybridAbstract readReview
In one paragraph

Review in United European gastroenterology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 86 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Pharmacotherapy of Liver Fibrosis and Hepatitis: Recent Advances.Pharmaceuticals (Basel, Switzerland) · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Autoimmune Hepatitis: An Unusual Presentation.Journal of community hospital internal medicine perspectives · 2024
    Article
  16. Metabolic Reprogramming of CD4International journal of nanomedicine · 2024
    Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Simon PapeDepartment of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-3770-4568
Christoph SchrammEuropean Reference Network Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.
Tom Jg GeversDepartment of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands.
Radboud University Nijmegen · NLUniversität Hamburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune hepatitis is a rare and chronic liver disease that is characterised by increased serum transaminases and immunoglobulin G, inflammatory liver histology and presence of circulating autoantibodies. An autoimmune hepatitis diagnosis justifies life-long treatment in most patients in order to prevent development of cirrhosis and end-stage liver disease. The cornerstone of treatment is steroid induction therapy followed by maintenance therapy with azathioprine, which is effective in most cases. For patients who do not respond to standard treatment, second-line treatment with other immunosuppressants can be effective. Treatment should be aimed at biochemical remission of the disease, which is defined as normalization of transaminases and immunoglobulin G. Patients should be monitored intensively during the first months of treatment in order to monitor side-effects, assess symptoms and individualise treatment. Specialist consultation should be sought in difficult-to-treat patients. Future studies and networking initiatives should result in optimization of current treatment strategies in autoimmune hepatitis.

Indexed as

Alanine TransaminaseAspartate AminotransferasesAutoantibodiesAzathioprineDisease ProgressionGlucocorticoidsHepatitis, AutoimmuneHumansImmunoglobulin GImmunosuppressive AgentsInduction ChemotherapyMaintenance ChemotherapyMercaptopurineMycophenolic AcidPrednisoloneAlanine TransaminaseAspartate AminotransferasesAutoantibodiesAzathioprineGlucocorticoidsImmunoglobulin GImmunosuppressive AgentsMercaptopurineMycophenolic AcidPrednisoloneAutoimmune hepatitisclinical managementEuropean Association for Study of the Liverinduction therapyprednisoloneprednisone

Identifiers

PMID31700628
PMCPMC6826525
OpenAlexW2969253012

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.