ArticleInternational journal of pediatric endocrinology2019
Clinical and laboratory characteristics and follow up of 62 cases of ketotic hypoglycemia: a retrospective study.
Article in International journal of pediatric endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Glycogen storage disease type IX: Long-term follow-up of 52 patients from three European countries.Molecular genetics and metabolism reports · 2026Article
- Body mass index is associated with hypoglycaemia in children with acute vomiting and dehydration.PloS one · 2026Article
- Idiopathic Pathological Ketotic Hypoglycemia: Finding the Needle in a Haystack.Hormone research in paediatrics · 2025Review
- Idiopathic ketotic hypoglycemia in children: an update.Annals of pediatric endocrinology & metabolism · 2024Article
- Hypoglycaemia Metabolic Gene Panel Testing.Frontiers in endocrinology · 2022Review
- Towards enhanced understanding of idiopathic ketotic hypoglycemia: a literature review and introduction of the patient organization, Ketotic Hypoglycemia International.Orphanet journal of rare diseases · 2021Review
- A patient with glycogen storage disease type 0 and a novel sequence variant inThe Journal of international medical research · 2020Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIdiopathic ketotic hypoglycemia (KH) is the most common cause of hypoglycemia in non-diabetic children ages 0.5-6 years old and typically occurs after a period of poor food intake. There are no large studies looking at the value of common laboratory testing in children presenting with KH or how often other diagnoses are made.
objectivesTo examine the clinical presentations and the value of laboratory testing done in a cohort of children clinically diagnosed with KH.
methodsBilling records were searched from 2008 to 2017 for patients seen by the endocrine service for "hypoglycemia, not otherwise specified". Charts were reviewed to determine age, sex, presenting symptoms and testing ordered at the time of the consult. Through chart reviews after the event and parent phone calls, diagnoses other than idiopathic KH were searched.
resultsOf 150 charts reviewed, 62 had sufficient information to make a clinical diagnosis of KH (32 males 30 females, mean age 2.9 years). Most had a history of gastrointestinal illness or prolonged fasting but 29% had no apparent precipitating event. Laboratory testing was quite variable and while low serum CO
conclusionsIn the typical setting of a healthy 0.5-6 year-old child with an uncomplicated episode of KH following poor food intake and a normal exam including growth, hormonal and metabolic testing can safely be deferred. However, frequent recurrences and atypical features should prompt further investigation.
trial registrationNot needed for a retrospective chart review study.
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