Evidence map›Paper›PMID 31700258›Full record

ArticleJournal of ginseng research2019

Genotoxicity and subchronic toxicological study of a novel ginsenoside derivative 25-OCH

Wei Li, Xiangrong Zhang, Meng Ding, Yanfei Xin, Yaoxian Xuan, Yuqing Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ginseng research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Wei LiDepartment of Functional Food and Wine, Shenyang pharmaceutical University, Shenyang, China.
Xiangrong ZhangDepartment of Functional Food and Wine, Shenyang pharmaceutical University, Shenyang, China.
Meng DingDepartment of Functional Food and Wine, Shenyang pharmaceutical University, Shenyang, China.
Yanfei XinCenter of Safety Evaluation, Zhejiang Academy of Medical Sciences, Hangzhou, China.
Yaoxian XuanCenter of Safety Evaluation, Zhejiang Academy of Medical Sciences, Hangzhou, China.
Yuqing ZhaoDepartment of Functional Food and Wine, Shenyang pharmaceutical University, Shenyang, China.
Shenyang Pharmaceutical University · CNZhejiang Academy of Medical Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGinsenosides have been widely used clinically for many years and were regarded as very safe. However, a few researches on the toxicities of these kinds of agents showed that some ginsenosides may have side-effect on the rats or dogs. So it is extremely necessary to further clarify the potential toxicity of ginsenosides. This study was carried out to investigate long-term toxicity and genotoxicity of 25-methoxydammarane-3, 12, 20-triol (25-OCH

methodsTwenty-four beagle dogs were divided randomly into four treatment groups and repeatedly orally administered with 25-OCH

resultsThere was no 25-OCH

conclusionThe highest dose level of 25-OCH

Indexed as

25-OCH3-PPD, 25-methoxydammarane-3, 12, 20-triolalanine aminotransferase, ALTalbumin, ALBalkaline phosphatase, ALPaspartate aminotransferase, ASTbasophils, BASOBeagle dogchloride, Clcreatine phosphokinase, CKcreatinine, Creaeosinophils, EOSErythrocyte count, RBCgamma-glutamyl transferase, γ-GTGinsenosideglucose, GLUhematocrit, HCThemoglobin concentration distribution width, HDWhemoglobin concentration, HGBlymphocytes, LYMPHmean corpuscular hemoglobin concentration, MCHCmean corpuscular hemoglobin, MCHmean corpuscular volume, MCVmean platelet volume, MPVmicronucleated polychromatic erythrocytes, MNPCEmonocytes, MONOneutrophil cell, NEUTnormochromatic erythrocytes, NCEplatelets, PLTpolychromatic erythrocytes, PCEpotassium, Kprothrombin time, PTred cell distribution width, RDW%reticulocyte count, RETICsodium, NaSPSS, statistical package for social sciencesSubchronic toxicitytotal bilirubin, T.BILtotal calcium, TCatotal cholesterol, T.CHOtotal protein, T.Ptotal triglyceride, TGurea nitrogen, BUNwhite blood cells count, WBC

Identifiers

PMID31700258
PMCPMC6823799
OpenAlexW2807306168

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.