ArticleJournal of ginseng research2019
Simultaneous determination and difference evaluation of 14 ginsenosides in
Article in Journal of ginseng research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exploratory Systematic Review and Meta-Analysis ofNutrients · 2022Pooled it
- Nanogold-Lateral Flow Assay for Ginseng DNA Differentiation.Biosensors · 2025Article
- Diverse rare ginsenosides derived from ginsenoside Re in aqueous methanol solutionRSC advances · 2025Article
- Recent trends in ginseng research.Journal of natural medicines · 2024Review
- Biotransformation of Ginsenoside Rb1 to Ginsenoside Rd and 7 Rare Ginsenosides UsingACS omega · 2024Article
- Quantitative and Differential Analysis betweenMolecules (Basel, Switzerland) · 2023Article
- Microorganisms for Ginsenosides Biosynthesis: Recent Progress, Challenges, and Perspectives.Molecules (Basel, Switzerland) · 2023Review
- Genetic and molecular dissection of ginseng (Frontiers in plant science · 2023Article
- Quantitative Analysis and Differential Evaluation of Radix Bupleuri Cultivated in Different Regions Based on HPLC-MS and GC-MS Combined with Multivariate Statistical Analysis.Molecules (Basel, Switzerland) · 2022Article
- Rapid Discrimination and Prediction of Ginsengs from Three Origins Based on UHPLC-Q-TOF-MS Combined with SVM.Molecules (Basel, Switzerland) · 2022Article
- Effects of growth years on ginsenoside biosynthesis of wild ginseng and cultivated ginseng.BMC genomics · 2022Article
- Evaluation of storage period of fresh ginseng for quality improvement of dried and red processed varieties.Journal of ginseng research · 2022Article
- Machine learning methods to predict the cultivation age of Panacis Quinquefolii Radix.Chinese medicine · 2021Article
- Stem-leaves of Panax as a rich and sustainable source of less-polar ginsenosides: comparison of ginsenosides fromJournal of ginseng research · 2021Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundGinsenosides are not only the principal bioactive components but also the important indexes to the quality assessment of
methodsA high-performance liquid chromatography (HPLC) coupled with triple quadrupole mass spectrometer (MS) method was developed and used in the multiple reaction-monitoring (MRM) mode (HPLC-MRM/MS) for the quantitative analysis of ginsenosides. Multivariate statistical analysis, such as principal component analysis and partial least squares-discriminant analysis, was applied to discriminate ginseng samples of various cultivation areas and ages and to discover the differentially accumulated ginsenoside markers.
resultsThe developed HPLC-MRM/MS method was validated to be precise, accurate, stable, sensitive, and repeatable for the simultaneous determination of 14 ginsenosides. It was found that the 3- and 5-yr-old ginseng samples were differentiated distinctly by all means of multivariate statistical analysis, whereas the 4-yr-old samples exhibited similarity to either 3- or 5-yr-old samples in the contents of ginsenosides. Among the 14 detected ginsenosides, Rg1, Rb1, Rb2, Rc, 20(S)-Rf, 20(S)-Rh1, and Rb3 were identified as potential markers for the differentiation of cultivation ages. In addition, the 5-yr-old samples were able to be classified in cultivation area based on the contents of ginsenosides, whereas the 3- and 4-yr-old samples showed little differences in cultivation area.
conclusionThis study demonstrated that the HPLC-MRM/MS method combined with multivariate statistical analysis provides deep insight into the accumulation characteristics of ginsenosides and could be used to differentiate ginseng that are cultivated in different areas and ages.
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