ArticleNature medicine2019
Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells.
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Article in Nature medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 188 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
188citing papers in PubMed, 3 pooled it
16.7field-weighted citation impact, top 1% of its field
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Who cites it
188 citing papers in PubMed, 3 syntheses or guidelines pooled it, 264 citations in OpenAlex.
- Physical Activity and Metabolic Alterations in Children and Adolescents Across Different Weight Groups: A Systematic Review.European journal of sport science · 2026Pooled it
- The Role of Biomarkers in Atherothrombotic Stroke-A Systematic Review.International journal of molecular sciences · 2021Pooled it
- Preclinical techniques to investigate exercise training in vascular pathophysiology.American journal of physiology. Heart and circulatory physiology · 2021Pooled it
- Ambient Cold Exposure Modulates B-Cell Distribution via Glucocorticoid-CXCR4 Signaling.International journal of molecular sciences · 2026Article
- Modeling the Exposome in Murine Cardiovascular Disease.JACC. Basic to translational science · 2026Review
- Bone as a Biomarker of Ageing and Senescence: Connecting Musculoskeletal Health to Longevity via Diet, Nutrition and Exercise.Biology · 2026Review
- Exercise and Ferroptosis in Neurodegenerative Diseases: Direct Evidence, Mechanistic Links, and Translational Gaps.International journal of molecular sciences · 2026Review
- Accelerometer-Derived "Weekend Warrior" Physical Activity Pattern and Venous Thromboembolism Incidence and Mortality: A Prospective Cohort Study.Journal of the American Heart Association · 2026Article
- Cellular profile of hematopoietic stem cells mobilized by exercise versus G-CSF in healthy related donors.European journal of applied physiology · 2026Article
- Article
- Role of adipose tissue in cardiovascular health and diseases.Chinese medical journal · 2026Review
- CIITA/PRMT5 promote CD4BMC medicine · 2026Article
- Exercise Reverses Mental Stress-Induced Vascular Inflammation and Builds Stress Resilience.JACC. Basic to translational science · 2026Article
- Physical exercise mitigates chronic psychological stress-induced vascular inflammation via the BDNF-Kif4-TARM1 axis.Clinical and translational medicine · 2026Article
- Exercise pills for cardiometabolic health cannot mimic the exercise milieu.Trends in endocrinology and metabolism: TEM · 2026Review
- Joint effects of sleep behaviors and physical activity on brain structure and cognitive function.Fundamental research · 2026Article
- Mediation analysis of metabolic and inflammatory markers in the association between physical activity and musculoskeletal disease: Findings from NHANES 2013-2018.European journal of applied physiology · 2026Article
- Artery Tertiary Lymphoid Organs Establish Biological Platforms to Connect Atherosclerotic Plaques to the Brain.Current atherosclerosis reports · 2026Review
- The Link between Modifiable Risk Factors and Myeloid Disorders-From Plate to Pathogenesis.Blood cancer discovery · 2026Review
- Exercise-induced osteoimmune crosstalk: a virtuous cycle between bone remodeling and immune regulation.Frontiers in endocrinology · 2026Review
128 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
32 authors at 3 institutions in 3 countries.
Vanessa Frodermann *Center for Systems Biology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5566-6692
David Rohde *Center for Systems Biology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Gabriel CourtiesCenter for Systems Biology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Nicolas SevereDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Maximilian J SchlossCenter for Systems Biology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Hajera AmatullahGastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Cameron S McAlpineCenter for Systems Biology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Sebastian CremerCenter for Systems Biology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Friedrich F HoyerCenter for Systems Biology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Fei JiDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Ian D van KoeverdenLaboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Fanny HerissonCenter for Systems Biology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Lisa HonoldCenter for Systems Biology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Gustavo Santos MassonCenter for Systems Biology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Shuang ZhangCenter for Systems Biology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5570-5954
Jana GruneCenter for Systems Biology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Yoshiko IwamotoCenter for Systems Biology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Stephen P SchmidtCenter for Systems Biology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Gregory R WojtkiewiczCenter for Systems Biology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3148-8411
I-Hsiu LeeCenter for Systems Biology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Karin GustafssonDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Gerard PasterkampLaboratory for Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, the Netherlands.
Saskia C A de JagerLaboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0002-5233-0066
Ruslan I SadreyevDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Jean MacFadyenDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Peter LibbyDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Paul RidkerDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
David T ScaddenDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Kamila NaxerovaCenter for Systems Biology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7744-5110
Kate L JeffreyGastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Filip K SwirskiCenter for Systems Biology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Matthias NahrendorfCenter for Systems Biology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. mnahrendorf@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-4021-1887
Harvard University · USBrigham and Women's Hospital · USUniversity Medical Center Utrecht · NL
Funding
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Takara Leah Stanley · 1994 to 2026
$31.6MTranslational imaging and nanomedicine in inflammatory atherosclerosisP01HL131478 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Zahi A. Fayad · 2017 to 2026
$24.3MPROJECT 4: Somatic evolution of the hematopoietic system in cardiovascular diseaseP01HL142494 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Matthias Nahrendorf · 2019 to 2026
$19.5MImaging organ system interfaces in ischemic heart diseaseR35HL139598 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NAHRENDORF, MATTHIAS · 2018 to 2024
$6.9MCardiac MR and CT ResearchT32HL076136 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NEILAN, TOMAS G · 2004 to 2019
$4.9MSkeletal Phenotyping CoreP30AR066261 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI KRONENBERG, HENRY M. · 2014 to 2018
$3.5MLifestyle effects on hematopoiesis and atherosclerosisR01HL128264 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NAHRENDORF, MATTHIAS, SWIRSKI, FILIP K · 2015 to 2018
$3.3MArgonaute proteins in the mammalian antiviral responseR01AI107087 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI JEFFREY, KATE LOUISA · 2014 to 2018
$2.2MInterfering with the macrophage life cycle of atherosclerosisR01HL125428 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ANDERSON, DANIEL G, NAHRENDORF, MATTHIAS · 2017 to 2020
$1.9MNHLBI NIH HHS P01 HL131478NHLBI NIH HHS P01 HL142494NHLBI NIH HHS R01 HL125428NHLBI NIH HHS R01 HL128264NHLBI NIH HHS R35 HL139598NHLBI NIH HHS T32 HL076136NIAID NIH HHS R01 AI107087NIAMS NIH HHS P30 AR066261NIDDK NIH HHS P30 DK040561
Abstract
A sedentary lifestyle, chronic inflammation and leukocytosis increase atherosclerosis; however, it remains unclear whether regular physical activity influences leukocyte production. Here we show that voluntary running decreases hematopoietic activity in mice. Exercise protects mice and humans with atherosclerosis from chronic leukocytosis but does not compromise emergency hematopoiesis in mice. Mechanistically, exercise diminishes leptin production in adipose tissue, augmenting quiescence-promoting hematopoietic niche factors in leptin-receptor-positive stromal bone marrow cells. Induced deletion of the leptin receptor in Prrx1-creER
Indexed as
Physical Conditioning, AnimalAdipose TissueAnimalsAtherosclerosisCardiovascular DiseasesEpigenomeExerciseHematopoiesisHematopoietic Stem CellsHomeodomain ProteinsHumansInflammationLeukocytesLeukocytosisMiceReceptors, LeptinHomeodomain Proteinsleptin receptor, mousePrrx1 protein, mouseReceptors, Leptin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.