ArticleThe ISME journal2020
Production of ammonia as a low-cost and long-distance antibiotic strategy by Streptomyces species.
Article in The ISME journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 65 citations in OpenAlex.
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- Antifungal and other bioactive properties of the volatilome ofApplied and environmental microbiology · 2025Article
- Why Do FilamentousAnnual review of microbiology · 2025Review
- Antifungal and Immunomodulatory Activities of Brazilian SavannahPharmaceuticals (Basel, Switzerland) · 2025Article
- Impact of the alkaline volatile trimethylamine on the physiology ofMicrobiology spectrum · 2025Article
- Actinobacteria Warfare Against the Plant Pathogen Sclerotinia sclerotiorum: 2,4,6-Trimethylpyridine Identified as a Bacterial Derived Volatile With Antifungal Activity.Microbial biotechnology · 2025Article
- Protist size-dependent shifts of bacterial communities can reduce litter decomposition.ISME communications · 2025Article
- Cu-Ag nanoparticles positively modulating the endophytic bacterial community in tomato roots affected by bacterial wilt.Frontiers in microbiology · 2025Article
- Rescue of morphological defects inMicrobiology spectrum · 2024Article
- Enhancing Growth inMicroorganisms · 2024Article
- Root-associated Streptomyces produce galbonolides to modulate plant immunity and promote rhizosphere colonization.The ISME journal · 2024Article
- Co-inoculation ofFrontiers in plant science · 2024Article
- Two-tiered mutualism improves survival and competitiveness of cross-feeding soil bacteria.The ISME journal · 2023Article
- Novel strategies and advancement in reducing heavy metals from the contaminated environment.Archives of microbiology · 2022Review
- Air Ambulance: Antimicrobial Power of Bacterial Volatiles.Antibiotics (Basel, Switzerland) · 2022Review
- Bacterial marginolactones trigger formation of algal gloeocapsoids, protective aggregates on the verge of multicellularity.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Bacterial Long-Range Warfare: Aerial Killing of Legionella pneumophila by Pseudomonas fluorescens.Microbiology spectrum · 2021Article
- Ammonia Production byMicroorganisms · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Soil-inhabiting streptomycetes are nature's medicine makers, producing over half of all known antibiotics and many other bioactive natural products. However, these bacteria also produce many volatiles, molecules that disperse through the soil matrix and may impact other (micro)organisms from a distance. Here, we show that soil- and surface-grown streptomycetes have the ability to kill bacteria over long distances via air-borne antibiosis. Our research shows that streptomycetes do so by producing surprisingly high amounts of the low-cost volatile ammonia, dispersing over long distances to inhibit the growth of Gram-positive and Gram-negative bacteria. Glycine is required as precursor to produce ammonia, and inactivation of the glycine cleavage system nullified ammonia biosynthesis and concomitantly air-borne antibiosis. Reduced expression of the porin master regulator OmpR and its cognate kinase EnvZ is used as a resistance strategy by E. coli cells to survive ammonia-mediated antibiosis. Finally, ammonia was shown to enhance the activity of canonical antibiotics, suggesting that streptomycetes adopt a low-cost strategy to sensitize competitors for antibiosis from a distance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.