Evidence map›Paper›PMID 31700106›Full record

ArticleScientific reports2019

The inflammasome NLRP3 plays a dual role on mouse corpora cavernosa relaxation.

Rafael S Fais, Fernanda L Rodrigues, Camila A Pereira, Allan C Mendes, Fabíola Mestriner, Rita C Tostes, Fernando S Carneiro

Erratum issuedAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. A KBiomolecules · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Cardiometabolic Disorder and Erectile Dysfunction.Cell biochemistry and biophysics · 2024
    Review
  6. Review
  7. Article
  8. NLRP3 activation contributes to endothelin-1-induced erectile dysfunction.Journal of cellular and molecular medicine · 2023
    Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Rafael S FaisDepartments of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil.
Fernanda L RodriguesDepartments of Physiology, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil.
Camila A PereiraDepartments of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil.
Allan C MendesDepartments of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil.
Fabíola MestrinerDepartments of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil.
Rita C TostesDepartments of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil.
Fernando S CarneiroDepartments of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil. fsilvac@usp.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NLRP3 plays a role in vascular diseases. Corpora cavernosa (CC) is an extension of the vasculature. We hypothesize that NLRP3 plays a deleterious role in CC relaxation. Male C57BL/6 (WT) and NLRP3 deficient (NLRP3

Indexed as

Muscle RelaxationAnimalsGene DeletionInflammasomesMaleMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinPenisSignal TransductionInflammasomesNLR Family, Pyrin Domain-Containing 3 Protein

Identifiers

PMID31700106
PMCPMC6838322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.