ArticleScientific reports2019
The integration of metabolome and proteome reveals bioactive polyphenols and hispidin in ARTP mutagenized Phellinus baumii.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 33 citations in OpenAlex.
- Advances in high-throughput mutation breeding systems integrating atmospheric and room-temperature plasma (ARTP) with droplet-based microfluidics.Microbial cell factories · 2025Review
- Functional Characterization of an Aldol Condensation Synthase PheG for the Formation of Hispidin from Phellinus Igniarius.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Comparison of antioxidant and antimicrobial activities of submerged culture mycelium and basidioma extracts ofFood science and biotechnology · 2025Article
- Evaluating the Therapeutic Effect of Hispidin on Prostate Cancer Cells.International journal of molecular sciences · 2024Article
- Comparative genomic analysis of Sanghuangporus sanghuang with other Hymenochaetaceae species.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Production of hispidin polyphenols from medicinal mushroomChinese herbal medicines · 2023Article
- Application of Atmospheric and Room-Temperature Plasma (ARTP) to Microbial Breeding.Current issues in molecular biology · 2023Review
- Article
- Transcriptome Analysis Reveals the Putative Polyketide Synthase Gene Involved in Hispidin Biosynthesis inMycobiology · 2023Article
- Article
- Genomic and Metabolomic Analyses of the Medicinal FungusJournal of fungi (Basel, Switzerland) · 2022Article
- Diverse Metabolites and Pharmacological Effects from the BasidiomycetesAntibiotics (Basel, Switzerland) · 2022Review
- Article
- Edible and medicinal fungi breeding techniques, a review: Current status and future prospects.Current research in food science · 2022Review
- Mutation breeding ofPeerJ · 2022Article
- Therapeutic Potential of Hispidin-Fungal and Plant Polyketide.Journal of fungi (Basel, Switzerland) · 2021Review
- Whole-genome sequence ofJournal of advanced research · 2020Article
- Development of optimal steam explosion pretreatment and highly effective cell factory for bioconversion of grain vinegar residue to butanol.Biotechnology for biofuels · 2020Article
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10 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Phellinus baumii, also called "Sang Huang" in China, is broadly used as a kind of health food or folk medicine in Asia for its high biological activities, e.g. anti-tumor, anti-oxidation and anti-inflammatory activities. Although some previous studies have indicated that polysaccharides and flavonoids showed the activity of inhibiting tumor cells, the active metabolites of P. baumii needs further research. In our study, a stable P. baumii mutant (A67), generated by ARTP mutagenesis strategy, showed more significantly inhibiting tumor cells and enhancing antioxidant activity. Our further studies found that the increase of polyphenols content, especially hispidin, was an important reason of the biological activity enhancement of A67. According to the results of the integrated metabolome and proteome study, the increase of polyphenol content was caused by upregulation of the phenylpropanoid biosynthesis. This study expanded the understanding of active compounds and metabolic pathway of P. baumii.
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