ArticleScientific reports2019
Human beings as islands of stability: Monitoring body states using breath profiles.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Breath, beyond blood: the role of gaseous biofluids in medical research.Medical gas research · 2027Article
- Evaluating the VOCORDER device for early disease detection through breath analysis: study protocol for a two-phase clinical study.BMJ open · 2026Article
- Is Digital Drying an Effective Method for Infrared Spectroscopy of Gaseous Biofluid?Analytical chemistry · 2025Article
- Infrared Spectroscopic Profiling of Volatile Metabolites from Uropathogenic Bacteria: Basic Investigations toward Rapid UTI Diagnostics.Analytical chemistry · 2025Article
- Measurement of Bacterial Headspaces by FT-IR Spectroscopy Reveals Distinct Volatile Organic Compound Signatures.Analytical chemistry · 2025Article
- Article
- Non-Invasive Disease Specific Biomarker Detection Using Infrared Spectroscopy: A Review.Molecules (Basel, Switzerland) · 2023Review
- Detection of SARS-CoV-2 infection by exhaled breath spectral analysis: Introducing a ready-to-use point-of-care mass screening method.EClinicalMedicine · 2022Article
- Clinical trial and detection of SARS-CoV-2 by a commercial breath analysis test based on Terahertz technology.PloS one · 2022Article
- Two-dimensional Infrared Spectroscopy Reveals Better Insights of Structure and Dynamics of Protein.Molecules (Basel, Switzerland) · 2021Review
- Experimental Investigation on Water Adsorption Using Laser Photoacoustic Spectroscopy and Numerical Simulations.Materials (Basel, Switzerland) · 2021Article
- Towards reliable diagnostics of prostate cancer via breath.Scientific reports · 2021Article
- Monitoring the Reaction of the Body State to Antibiotic Treatment againstMolecules (Basel, Switzerland) · 2021Article
- Physiological Network From Anthropometric and Blood Test Biomarkers.Frontiers in physiology · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
By checking the reproducibility of conventional mid-infrared Fourier spectroscopy of human breath in a small test study (15 individuals), we found that a set of volatile organic compounds (VOC) of the individual breath samples remains reproducible at least for 18 months. This set forms a unique individual's "island of stability" (IOS) in a multidimensional VOC concentration space. The IOS stability can simultaneously be affected by various life effects as well as the onset of a disease. Reflecting the body state, they both should have different characteristics. Namely, they could be distinguished by different temporal profiles: In the case of life effects (beverage intake, physical or mental exercises, smoking etc.), there is a non-monotonic shift of the IOS position with the return to the steady state, whereas a progressing disease corresponds to a monotonic IOS shift. As a first step of proving these dependencies, we studied various life effects with the focus on the strength and characteristic time of the IOS shift. In general, our results support homeostasis on a long time scale of months, allostasis on scales of hours to weeks or until smoke quitting for smokers, as well as resilience in the case of recovery from a disease.
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