Evidence map›Paper›PMID 31699990›Full record

ArticleNature communications2019

Enhanced and unified anatomical labeling for a common mouse brain atlas.

Uree Chon, Daniel J Vanselow, Keith C Cheng, Yongsoo Kim

Abstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Central amygdalar PKCδ neurons mediate fentanyl withdrawal.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Uree ChonDepartment of Neural and Behavioral Sciences, College of Medicine, Penn State University, Hershey, PA, USA.ORCID http://orcid.org/0000-0002-5620-5430
Daniel J VanselowDepartment of Pathology, College of Medicine, Penn State University, Hershey, PA, USA.ORCID http://orcid.org/0000-0002-9221-8634
Keith C ChengDepartment of Pathology, College of Medicine, Penn State University, Hershey, PA, USA.ORCID http://orcid.org/0000-0002-5350-5825
Yongsoo KimDepartment of Neural and Behavioral Sciences, College of Medicine, Penn State University, Hershey, PA, USA. yuk17@psu.edu.ORCID http://orcid.org/0000-0002-4277-0279

Funding

Groundwork for a Synchrotron MicroCT Imaging Resource for Biology (SMIRB)R24OD018559 · OD · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI CHENG, KEITH CHI · 2015 to 2022
$6.4M
Understanding cellular architecture of the neurovascular unit and its function in the whole mouse brainR01NS108407 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KIM, YONGSOO · 2018 to 2022
$3.1M
Brain-wide input and output wiring diagram of oxytocin neurons and its function in claustrum-endopiriform complexR01MH116176 · NIMH · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KIM, YONGSOO · 2018 to 2022
$2.4M
NIH HHS R24 OD018559NIMH NIH HHS R01 MH116176NINDS NIH HHS R01 NS108407
6 · The paper itself

Abstract

Anatomical atlases in standard coordinates are necessary for the interpretation and integration of research findings in a common spatial context. However, the two most-used mouse brain atlases, the Franklin-Paxinos (FP) and the common coordinate framework (CCF) from the Allen Institute for Brain Science, have accumulated inconsistencies in anatomical delineations and nomenclature, creating confusion among neuroscientists. To overcome these issues, we adopt here the FP labels into the CCF to merge the labels in the single atlas framework. We use cell type-specific transgenic mice and an MRI atlas to adjust and further segment our labels. Moreover, detailed segmentations are added to the dorsal striatum using cortico-striatal connectivity data. Lastly, we digitize our anatomical labels based on the Allen ontology, create a web-interface for visualization, and provide tools for comprehensive comparisons between the CCF and FP labels. Our open-source labels signify a key step towards a unified mouse brain atlas.

Indexed as

Atlases as TopicAnimalsBrainImaging, Three-DimensionalMagnetic Resonance ImagingMiceMice, TransgenicTerminology as Topic

Identifiers

PMID31699990
PMCPMC6838086

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.