ArticleProceedings of the National Academy of Sciences of the United States of America2019
aPKCi triggers basal extrusion of luminal mammary epithelial cells by tuning contractility and vinculin localization at cell junctions.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Special Issue "Molecular Research and Cellular Biology of Breast Cancer".International journal of molecular sciences · 2026Article
- Epithelial guardians against cancer: integrating cell competition and extrusion in early tumor control.Discover oncology · 2025Review
- Basal Invasion of Cancer Cells Driven by Cell-Cell Interactions: An Affirmative Role of Cell Competition in Cancer Progression.Cancer science · 2025Review
- Large-Scale Bioprinting of Human Epiblast-Like Models Featuring Disc-Shaped Morphogenesis and Gastrulation Events.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Force transmission is a master regulator of mechanical cell competition.Nature materials · 2025Article
- Different Biomechanical Cell Behaviors in an Epithelium Drive Collective Epithelial Cell Extrusion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Basal delamination during mouse gastrulation primes pluripotent cells for differentiation.Developmental cell · 2024Article
- Cell polarity changes in cancer initiation and progression.The Journal of cell biology · 2024Review
- The role and mechanism of compressive stress in tumor.Frontiers in oncology · 2024Review
- Polarity signaling balances epithelial contractility and mechanical resistance.Scientific reports · 2023Article
- Invadopodia enable cooperative invasion and metastasis of breast cancer cells.Communications biology · 2022Article
- Surface-tension-induced budding drives alveologenesis in human mammary gland organoids.Nature physics · 2021Article
- Early mechanical selection of cell extrusion and extrusion signaling in cancer.Current opinion in cell biology · 2021Review
- Organoid models for mammary gland dynamics and breast cancer.Current opinion in cell biology · 2020Review
- A new pipeline for pathophysiological analysis of the mammary gland based on organoid transplantation and organ clearing.Journal of cell science · 2020Article
- Symmetry Breaking and Epithelial Cell Extrusion.Cells · 2020Review
- Dysfunctional Mechanotransduction through the YAP/TAZ/Hippo Pathway as a Feature of Chronic Disease.Cells · 2020Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metastasis is the main cause of cancer-related deaths. How a single oncogenic cell evolves within highly organized epithelium is still unknown. Here, we found that the overexpression of the protein kinase atypical protein kinase C ι (aPKCi), an oncogene, triggers basally oriented epithelial cell extrusion in vivo as a potential mechanism for early breast tumor cell invasion. We found that cell segregation is the first step required for basal extrusion of luminal cells and identify aPKCi and vinculin as regulators of cell segregation. We propose that asymmetric vinculin levels at the junction between normal and aPKCi
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