Evidence map›Paper›PMID 31699792›Full record

ArticleHaematologica2020

Src family kinase-mediated vesicle trafficking is critical for neutrophil basement membrane penetration.

Ina Rohwedder, Angela R M Kurz, Monika Pruenster, Roland Immler, Robert Pick, Tanja Eggersmann, Sarah Klapproth, Jennifer L Johnson, Sergi Masgrau Alsina, Clifford A Lowell and 3 more

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

  1. The Src-Family Kinases Hck, Fgr and Lyn Drive Immune Complex-Mediated Glomerulonephritis Through the Syk Tyrosine Kinase.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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  2. Review
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  6. Review
  7. Bosutinib mitigates inflammation in experimental sepsis.European journal of clinical investigation · 2025
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  11. Neutrophils-biology and diversity.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
    Review
  12. Article
  13. Therapeutic inhibition of CXCR1/2: where do we stand?Internal and emergency medicine · 2023
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Dexamethasone PromotesJournal of fungi (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Ina RohwedderWalter-Brendel-Center of Experimental Medicine, Institute of Cardiovascular Physiology and Pathophysiology, Klinikum der Universität, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany.
Angela R M KurzWalter-Brendel-Center of Experimental Medicine, Institute of Cardiovascular Physiology and Pathophysiology, Klinikum der Universität, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany.
Monika PruensterWalter-Brendel-Center of Experimental Medicine, Institute of Cardiovascular Physiology and Pathophysiology, Klinikum der Universität, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany.
Roland ImmlerWalter-Brendel-Center of Experimental Medicine, Institute of Cardiovascular Physiology and Pathophysiology, Klinikum der Universität, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany.
Robert PickWalter-Brendel-Center of Experimental Medicine, Institute of Cardiovascular Physiology and Pathophysiology, Klinikum der Universität, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany.
Tanja EggersmannWalter-Brendel-Center of Experimental Medicine, Institute of Cardiovascular Physiology and Pathophysiology, Klinikum der Universität, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany.
Sarah KlapprothWalter-Brendel-Center of Experimental Medicine, Institute of Cardiovascular Physiology and Pathophysiology, Klinikum der Universität, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany.
Jennifer L JohnsonDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
Sergi Masgrau AlsinaWalter-Brendel-Center of Experimental Medicine, Institute of Cardiovascular Physiology and Pathophysiology, Klinikum der Universität, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany.
Clifford A LowellDepartment of Laboratory Medicine, University of California, San Francisco, CA, USA.
Attila MócsaiDepartment of Physiology, Semmelweis University School of Medicine, Budapest, Hungary.
Sergio D CatzDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
Markus SperandioWalter-Brendel-Center of Experimental Medicine, Institute of Cardiovascular Physiology and Pathophysiology, Klinikum der Universität, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany markus.sperandio@lmu.de.
Ludwig-Maximilians-Universität München · DEScripps Research Institute · USSemmelweis University · HUUniversity of California, San Francisco · US

Funding

Vesicular trafficking mechanisms regulating granulocyte functionR01HL088256 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI Sergio Daniel Catz · 2009 to 2026
$9.0M
Regulation of Innate Immune Signaling by Lyn KinaseR01AI113272 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOWELL, CLIFFORD A · 2015 to 2019
$2.0M
Small Molecule inhibitors of late endosomal pro-inflammatory signalingR01AR070837 · NIAMS · SCRIPPS RESEARCH INSTITUTE, THE · PI CATZ, SERGIO DANIEL, ROSEN, HUGH · 2017 to 2019
$1.3M
NHLBI NIH HHS R01 HL088256NIAID NIH HHS R01 AI113272NIAMS NIH HHS R01 AR070837
6 · The paper itself

Abstract

Leukocyte recruitment into inflamed tissue is highly dependent on the activation and binding of integrins to their respective ligands, followed by the induction of various signaling events within the cell referred to as outside-in signaling. Src family kinases (SFK) are the central players in the outside-in signaling process, assigning them a critical role for proper immune cell function. Our study investigated the role of SFK on neutrophil recruitment

Indexed as

Neutrophilssrc-Family KinasesAnimalsBasement MembraneMiceMice, KnockoutProto-Oncogene ProteinsProto-Oncogene Proteinssrc-Family Kinases

Identifiers

PMID31699792
PMCPMC7327629
OpenAlexW2982941623

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.