Trial reportBMJ open2019
Optical coherence tomography (OCT) in unconscious and systemically unwell patients using a mobile OCT device: a pilot study.
Trial report in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- The Ocular Signature of TBI: A Narrative Review of Structural Changes and Potential Candidate Biomarkers.Life (Basel, Switzerland) · 2026Review
- Non-invasive intracranial pressure estimation in the intensive care unit: narrative review of methods and clinical applications.Intensive care medicine · 2026Review
- Imaging the choroidal microvasculature in intensive and high dependency care unit patients: a pilot study.BMJ open · 2026Article
- Retinal Perfusion and Injury in Sepsis and after Major Surgery.Ophthalmology science · 2026Article
- Mobile Robotic Optical Coherence Tomography System for Ophthalmic Imaging in Clinical Environments.... International Symposium on Medical Robotics. International Symposium on Medical Robotics · 2025Article
- Noninvasive Bedside Approaches for Assessing Microvascular Dysfunction.Journal of vascular research · 2025Review
- Investigation of the Reproducibility of Portable Optical Coherence Tomography in Diabetic Macular Edema.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Handheld contact-type OCT and color fundus system for retinal imaging.Biomedical optics express · 2024Article
- Retinal changes and cardiac biomarker assessment in relation to chronic kidney disease: a single centre study.BMC nephrology · 2023Article
- Reliability of Optical Coherence Tomography Angiography Retinal Blood Flow Analyses.Translational vision science & technology · 2023Observational
- Convolutional Neural Network-Based Automated Quality Assessment of OCT and OCT Angiography Image Maps in Individuals With Neurodegenerative Disease.Translational vision science & technology · 2023Article
- A Neuro-Ophthalmologist's Guide to Advances in Intracranial Pressure Measurements.Eye and brain · 2023Review
- Vitreoretinal biomarkers of retinopathy of prematurity using handheld optical coherence tomography: a review.Frontiers in pediatrics · 2023Review
- Modelling Neurological Diseases in Large Animals: Criteria for Model Selection and Clinical Assessment.Cells · 2022Review
- Portable boom-type ultrahigh-resolution OCT with an integrated imaging probe for supine position retinal imaging.Biomedical optics express · 2022Article
- Optical Coherence Tomography Combined with Fluorescein Fundus Angiography under Intelligent Algorithm to Evaluate the Clinical Efficacy of Ranibizumab Combined with Panretinal Photocoagulation in the Treatment of Macular Edema of Diabetic Retinopathy Patients.Computational and mathematical methods in medicine · 2022Article
- Optical coherence tomography angiography as a surrogate marker for end-organ resuscitation in sepsis: A review.Frontiers in medicine · 2022Review
- Stability of OCT and OCTA in the Intensive Therapy Unit Setting.Diagnostics (Basel, Switzerland) · 2021Article
- The Future Is Now: Incorporating Telemedicine into Glaucoma Care.Current ophthalmology reports · 2021Review
- Mechanisms of retinal damage in patients with COVID-19.Journal francais d'ophtalmologie · 2020Article
Corrections and comments
- Erratum issuedCorrection:2020
Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
objectiveThis study aims to evaluate the feasibility of retinal imaging in critical care using a novel mobile optical coherence tomography (OCT) device. The Heidelberg SPECTRALIS FLEX module (Heidelberg Engineering, Heidelberg, Germany) is an OCT unit with a boom arm, enabling ocular OCT assessment in less mobile patients.
designWe undertook an evaluation of the feasibility of using the SPECTRALIS FLEX for undertaking ocular OCT images in unconscious and critically ill patients.
settingThis study was conducted in the critical care unit of a large tertiary referral unit in the United Kingdom.
participants13 systemically unwell patients admitted to the critical care unit were purposively sampled to enable evaluation in patients with a range of clinical states. OUTCOME MEASURES: The primary outcome was the feasibility of acquiring clinically interpretable OCT scans on a consecutive series of patients. The standardised scanning protocol included macula-focused OCT, OCT optic nerve head (ONH), OCT angiography (OCTA) of the macula and ONH OCTA.
resultsOCT images from 13 patients were attempted. The success rates of each scan type are 84% for OCT macula, 76% for OCT ONH, 56% for OCTA macula and 36% for OCTA ONH. The overall mean success rate of scans per patient was 64% (95% CI 46% to 81%). Clinicians reported clinical value in 100% scans which were successfully obtained, including both ruling in and ruling out relevant ocular complications such as corneal thinning, macular oedema and optic disc swelling. The most common causes of failure to achieve clinically interpretable scans were inadequately sustained OCT alignment in delirious patients and a compromised ocular surface due to corneal exposure.
conclusionsThis prospective evaluation indicates the feasibility and potential clinical value of the SPECTRALIS FLEX OCT system on the critical care unit. Portable OCT systems have the potential to bring instrument-based ophthalmic assessment to critically ill patients, enabling detection and micron-level monitoring of ocular complications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.