SynthesisBMJ open2019
Comorbidity in adults with traumatic brain injury and all-cause mortality: a systematic review.
Synthesis in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sleep in patients with traumatic brain injury: a systematic review and meta-analysis of actigraphy studies.Sleep · 2025Pooled it
- EEG functional connectivity measures for differentiating 6-month consciousness-related outcome after brain injury.BMC medical imaging · 2026Article
- ASA class is independently associated with 30-day mortality after mild traumatic brain injury with intracranial injury: a national retrospective cohort study.Acta neurochirurgica · 2026Article
- Overall outcome, functioning, and disability in older adults 3 to 14 years after traumatic brain injury.PM & R : the journal of injury, function, and rehabilitation · 2026Article
- Sex and Age Differences in Outcomes of Traumatic Brain Injury: Findings from the Japan Neurotrauma Data Bank.Journal of clinical medicine · 2026Article
- Molecular characterization ofOpen veterinary journal · 2026Article
- Predictors of in-hospital mortality in traumatic subarachnoid hemorrhage: a nationwide study of 67,684 patients in Germany.Brain & spine · 2026Article
- Trends and Disparities in Fall-Related Head Injury Mortality Among Middle-Aged and Older Adults (>55 Years) in the United States: A 21-Year National Analysis (1999-2020).Brain and behavior · 2025Article
- Revolutionizing cross professional collaboration outcomes in TBI: emerging trends in diagnostics, personalized medicine, technological innovations and neurorehabilitation.Brain informatics · 2025Review
- Traumatic Brain Injury and Dementia: Mechanisms, Risk Stratification, and Clinical Management.Journal of clinical neurology (Seoul, Korea) · 2025Review
- A study of traumatic brain injury in Puerto Rico.The journal of the International Society of Physical and Rehabilitation Medicine · 2025Article
- Accelerated epigenetic ageing after burn injury.GeroScience · 2025Article
- Extracranial Effects of Traumatic Brain Injury: A Narrative Review.Clinics and practice · 2025Review
- ASA score is an independent predictor of 1-year outcome after moderate-to-severe traumatic brain injury.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Article
- Comparison of Video Laryngoscope (VL) and Intubating Laryngeal Mask Airway (I-LMA) for Endotracheal Intubation in a Manikin with Restricted Neck Motion.Archives of academic emergency medicine · 2025Article
- From acute injury to chronic comorbidity: Interrupted time series modeling of traumatic brain injury impact among post-9/11 veterans.PloS one · 2025Article
- ASA-score is associated with 90-day mortality after complicated mild traumatic brain injury - a retrospective cohort study.Acta neurochirurgica · 2024Article
- Cerebral hypoperfusion exacerbates traumatic brain injury in male but not female mice.The European journal of neuroscience · 2024Article
- Mortality Predictors for Adult Patients with Mild-to-Moderate Traumatic Brain Injury: A Literature Review.Neurology international · 2024Review
- Risk Factors Analysis for 90-Day Mortality of Adult Patients with Mild Traumatic Brain Injury in an Italian Emergency Department.Geriatrics (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectivesComorbidity in traumatic brain injury (TBI) has been recognised to alter the clinical course of patients and influence short-term and long-term outcomes. We synthesised the evidence on the effects of different comorbid conditions on early and late mortality post-TBI in order to (1) examine the relationship between comorbid condition(s) and all-cause mortality in TBI and (2) determine the influence of sociodemographic and clinical characteristics of patients with a TBI at baseline on all-cause mortality.
designSystematic review. DATA SOURCES: Medline, Central, Embase, PsycINFO and bibliographies of identified articles were searched from May 1997 to January 2019. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Included studies met the following criteria: (1) focused on comorbidity as it related to our outcome of interest in adults (ie, ≥18 years of age) diagnosed with a TBI; (2) comorbidity was detected by any means excluding self-report; (3) reported the proportion of participants without comorbidity and (4) followed participants for any period of time. DATA EXTRACTION AND SYNTHESIS: Two independent reviewers extracted the data and assessed risk of bias using the Quality in Prognosis Studies tool. Data were synthesised through tabulation and qualitative description.
resultsA total of 27 cohort studies were included. Among the wide range of individual comorbid conditions studied, only low blood pressure was a consistent predictors of post-TBI mortality. Other consistent predictors were traditional sociodemographic risk factors. Higher comorbidity scale, scores and the number of comorbid conditions were not consistently associated with post-TBI mortality.
conclusionsGiven the high number of comorbid conditions that were examined by the single studies, research is required to further substantiate the evidence and address conflicting findings. Finally, an enhanced set of comorbidity measures that are suited for the TBI population will allow for better risk stratification to guide TBI management and treatment. PROSPERO REGISTRATION NUMBER: CRD42017070033.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.