ArticleJournal of vascular surgery2020
Asymptomatic carotid stenosis is associated with mobility and cognitive dysfunction and heightens falls in older adults.
Article in Journal of vascular surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- A cross-sectional study: carotid artery stiffness in individuals with varying cardiovascular disease risk using shear wave elasticity.BMC cardiovascular disorders · 2026Observational
- Asymptomatic Carotid Stenosis is Associated With Mobility Dysfunction: Results From the InChianti Study.Vascular and endovascular surgery · 2025Article
- Cognitive impairment and quality of life among patients with carotid artery stenosis in Jordan: a cross-sectional study.Scientific reports · 2025Article
- Characterizing vascular function in mouse models of Alzheimer's disease, atherosclerosis, and mixed Alzheimer's and atherosclerosis.Neurophotonics · 2025Article
- The role of the Mediterranean diet in the treatment of cognitive dysfunction in patients with type 2 diabetes mellitus.Frontiers in nutrition · 2025Article
- Gait speed after mild stroke/transient ischemic attack was associated with long-term adverse outcomes: A cohort study.Annals of clinical and translational neurology · 2024Article
- Cerebrovascular dysregulation and postoperative cognitive alterations after carotid endarterectomy.GeroScience · 2024Article
- An international, multispecialty, expert-based Delphi Consensus document on controversial issues in the management of patients with asymptomatic and symptomatic carotid stenosis.Journal of vascular surgery · 2024Review
- Static and dynamic brain functional connectivity patterns in patients with unilateral moderate-to-severe asymptomatic carotid stenosis.Frontiers in aging neuroscience · 2024Article
- Sonographic assessment of carotid intima-media thickness in healthy young Thai adults.Imaging science in dentistry · 2023Article
- Article
- Cognitive impairment in asymptomatic cerebral arterial stenosis: a P300 study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Study of cognitive function in patients with severe asymptomatic carotid artery stenosis by a computerized neuropsychological assessment device.Frontiers in psychology · 2023Article
- Associations between carotid atherosclerotic plaque characteristics determined by magnetic resonance imaging and improvement of cognition in patients undergoing carotid endarterectomy.Quantitative imaging in medicine and surgery · 2022Article
- The microbiota-gut-brain axis participates in chronic cerebral hypoperfusion by disrupting the metabolism of short-chain fatty acids.Microbiome · 2022Article
- Revascularization for asymptomatic carotid artery stenosis improves balance and mobility.Journal of vascular surgery · 2021Article
- Asymptomatic carotid artery stenosis is associated with cerebral hypoperfusion.Journal of vascular surgery · 2021Article
- Gait and Balance Disorder in Patients with Transient Ischemic Attack or Minor Stroke.Neuropsychiatric disease and treatment · 2021Article
- A New Rat Model of Chronic Cerebral Hypoperfusion Resulting in Early-Stage Vascular Cognitive Impairment.Frontiers in aging neuroscience · 2020Article
- Animal Models of Chronic Cerebral Hypoperfusion: From Mouse to Primate.International journal of molecular sciences · 2019Review
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
- Commented on byReply.2020
- Commented on by
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAtherosclerosis of the carotid bifurcation with plaque formation causes asymptomatic carotid artery stenosis (ACAS), which may also be associated with cerebral hypoperfusion. Cerebral hypoperfusion adversely affects multiple aspects of mobility and cognition. This study tests the hypothesis that community-dwelling older adults with a 50% or greater diameter-reducing ACAS will have mobility and cognitive impairments that heighten their risk for falls.
methodsEighty community-dwelling adults completed a mobility assessment (Short Physical Performance Battery, Berg Balance Scale, Four Square Step Test, Dynamic Gait Index, Timed Up and Go, and gait speed), self-reported physical function (Activities-Specific Balance Confidence, SF-12 Physical Function Component), and cognitive tests (Mini-Mental State Examination). Falls were recorded for the past 6 months. Standardized carotid ultrasound examination classified participants into no stenosis (<50% diameter reduction) (n = 54), moderate stenosis (50%-69%) (n = 17), and high-grade stenosis (70%-99%) (n = 9) groups. Linear and logistic regression analyses determined the associations between these measures and the degree of stenosis (three groups).
resultsLogistic regression analysis showed their degree of stenosis was associated with reductions in mobility (Short Physical Performance Battery [P = .008], Berg Balance Scale [P = .0008], Four Square Step Test [P = .005], DGI [P = .0001], TUG [P = .0004], gait speed [P = .02]), perceived physical function (ABC [P < .0001], SF-12 Physical Function Component [P < .0001]), and cognition (MMSE [P = .003]). Adults with moderate- and high-grade stenosis had a greater incidence of falls compared with those without stenosis (relative risk, 2.86; P = .01). Results remained unchanged after adjustment for age, sex and cardiovascular risk factors.
conclusionsACAS is associated with impaired mobility and cognition that are accompanied with increased fall risk. These impairments increased with worsening severity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.