ArticleReproductive biology and endocrinology : RB&E2019
Serum and follicular fluid thyroid hormone levels and assisted reproductive technology outcomes.
Article in Reproductive biology and endocrinology : RB&E, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Changes in thyroid function during controlled ovarian hyperstimulation (COH) and its impact on assisted reproduction technology (ART) outcomes: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2021Pooled it
- Ovarian Reserve and Anti-Thyroid Peroxidase Antibodies in Euthyroid Infertile Women: A Cross-Sectional Study.Journal of family & reproductive health · 2026Article
- Resolved hyperthyroidism before IVF is not associated with improved cumulative live birth rates: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Peripheral organ crosstalk in the regulation of ovarian endocrine function and reproductive homeostasis.Life medicine · 2025Review
- Serum estradiol on the day of final oocyte maturation and outcome of assisted reproduction in women with thyroid autoimmunity.Scientific reports · 2025Article
- Metabolomics of follicular fluid reveals the impact of heat stress on oocyte pick-up and in vitro embryo production efficiency in dairy cows.Journal of animal science · 2025Article
- Thyroid transcriptomic profiling reveals the differential regulation of lncRNA and mRNA related to prolificacy in Small Tail Han sheep withAnimal biotechnology · 2024Article
- Autoimmune thyroid disease and ovarian hypofunction: a review of literature.Journal of ovarian research · 2024Review
- Impaired embryo development potential associated with thyroid autoimmunity in euthyroid infertile women with diminished ovarian reserve.Frontiers in endocrinology · 2024Article
- Elucidation of the genetic determination of clutch traits in Chinese local chickens of the Laiwu Black breed.BMC genomics · 2023Article
- Comparisons of conventional in vitro fertilization versus intracytoplasmic sperm injection in women with thyroid autoimmunity and non-male factor infertility, a propensity score matching analysis.Scientific reports · 2023Article
- Metabolomic analysis of follicular fluid from women with Hashimoto thyroiditis.Scientific reports · 2023Article
- Concomitant Autoimmunity in Endometriosis Impairs Endometrium-Embryo Crosstalk at the Implantation Site: A Multicenter Case-Control Study.Journal of clinical medicine · 2023Article
- Impact of Antithyroperoxidase Antibodies (Anti-TPO) on Ovarian Reserve and Early Embryo Development in Assisted Reproductive Technology Cycles.International journal of molecular sciences · 2023Article
- Research progress on the impact of anxiety and depression on embryo transfer outcomes ofZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2023Review
- Hashimoto's thyroiditis, vitiligo, anemia, pituitary hyperplasia, and lupus nephritis-A case report of autoimmune polyglandular syndrome type III C + D and literature review.Frontiers in pediatrics · 2023Article
- IFN-γ differential expression in the hypothalamus-pituitary-ovary axis of thyroidectomized rats.BMC endocrine disorders · 2022Article
- Sperm Physiological Response to Female Serum-Potential New Insights into the Reproductive Incompatibility Diagnostics.International journal of molecular sciences · 2022Article
- Extracellular cell-free RNA profile in human large follicles and small follicles.Frontiers in cell and developmental biology · 2022Article
- Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance.Nature communications · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe objective ofthis study was to assess the association between thyroid hormone (TH) levels in follicular fluid (FF) and serum and to determine whether THs impact assisted reproductive technology (ART) outcomes.
methodsThis study enrolled 299 women undergoing ART. Blood samples were drawn on the day of human chorionic gonadotrophin (HCG) administrationand analysed for thyroid-stimulating hormone (TSH), thyroxine(T4), triiodothyronine(T3),free T4 (fT4),free T3(fT3), thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb) levels. FF was obtained on the oocyte pick up (OPU) day and analysed forTSH, T4, T3, fT4, fT3, TPOAb, TgAb and estradiol levels.
results(1) There were significant positive correlations between serum and FF TH and thyroid autoantibody levels. Statistically significant differences were discovered in serum and FF levels of TSH (p ≤ 0.001), T4 (p ≤ 0.001), T3 (p ≤ 0.001), TPOAbs (p ≤ 0.001) and TGAbs (p = 0.021). (2) Serum T4 levels [121.9(104.8,140.8) vs 114.1(98.6,130.6) nmol/l, p = 0.026], serum fT4 levels[(19.0(17.7,21.8) vs 18.6(17.0,20.1) pmol/l, p = 0.026], serum T4/T3 ratios [62.5 (55.7, 66.2) vs 59.4 (53.4, 64.9), p = 0.029], FF fT4 levels [19.0(17.5,21.3) vs 18.1(16.8,19.9) pmol/l, p = 0.009] and FF T4/T3 ratios [52.6 (46.4, 57.3) vs 50.0 (43.7, 53.1), p = 0.004] were significantly higher in the successful pregnancy group than the implantation failure group. (3) Spearman's rank correlation analysis revealed positive associations of both the FF T4/T3 ratio and serum TSH levels with the numbers of retrieved oocytes (total or MII) and embryos (fertilized, cleavage, and good quality).
conclusionsTH levels in FF are strongly correlated with those in serum on the HCG day, and THs on the HCG day may affect ART outcomes.
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