Evidence map›Paper›PMID 31699096›Full record

ArticleParticle and fibre toxicology2019

Silicon dioxide nanoparticles induce insulin resistance through endoplasmic reticulum stress and generation of reactive oxygen species.

Hailong Hu, Xingpei Fan, Qian Guo, Xiangjuan Wei, Daqian Yang, Boya Zhang, Jing Liu, Qiong Wu, Yuri Oh, Yujie Feng and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Particle and fibre toxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 58 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Hailong HuSchool of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, No. 92 West Da-zhi Street, Harbin, Heilongjiang, 150001, China.
Xingpei FanSchool of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, No. 92 West Da-zhi Street, Harbin, Heilongjiang, 150001, China.
Qian GuoSchool of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, No. 92 West Da-zhi Street, Harbin, Heilongjiang, 150001, China.
Xiangjuan WeiSchool of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, No. 92 West Da-zhi Street, Harbin, Heilongjiang, 150001, China.
Daqian YangSchool of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, No. 92 West Da-zhi Street, Harbin, Heilongjiang, 150001, China.
Boya ZhangSchool of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, No. 92 West Da-zhi Street, Harbin, Heilongjiang, 150001, China.
Jing LiuSchool of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, No. 92 West Da-zhi Street, Harbin, Heilongjiang, 150001, China.
Qiong WuSchool of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, No. 92 West Da-zhi Street, Harbin, Heilongjiang, 150001, China.
Yuri OhFaculty of Education, Wakayama University, Wakayama, Japan.
Yujie FengState Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, China.
Kun ChenThe Joint Research Center of Guangzhou University and Keele University for Gene Interference and Application, School of Life Science, Guangzhou University, Guangzhou, China.
Liping HouSchool of Life Sciences, Guangzhou University, Guangzhou, China.
Ning GuSchool of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, No. 92 West Da-zhi Street, Harbin, Heilongjiang, 150001, China. guning@hit.edu.cn.
Harbin Institute of Technology · CNGuangzhou University · CNWakayama University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSilicon dioxide nanoparticles (SiO

resultsIn the present study, mice were orally administered a series of doses of SiO

conclusionSilicon dioxide NPs induced IR through ER stress and generation of ROS, but SiO

Indexed as

Insulin ResistanceAdministration, OralAnimalsBlood GlucoseCytokinesEndocrine DisruptorsEndoplasmic Reticulum StressGene ExpressionGlucose Tolerance TestInsulin Receptor Substrate ProteinsLiverMaleMice, Inbred ICRNanoparticlesNF-kappa BPancreasBlood GlucoseCytokinesEndocrine DisruptorsInsulin Receptor Substrate ProteinsIrs1 protein, mouseNF-kappa BReactive Oxygen SpeciesSilicon DioxideBlood glucoseEndoplasmic reticulum stressMiceRNA-sequencingSilicon dioxide nanoparticles

Identifiers

PMID31699096
PMCPMC6836410
OpenAlexW2985091741

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.