ArticleBMC pulmonary medicine2019
Patterns of brain structural alteration in COPD with different levels of pulmonary function impairment and its association with cognitive deficits.
Article in BMC pulmonary medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
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Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Gray matter and cognitive alteration related to chronic obstructive pulmonary disease patients: combining ALE meta-analysis and MACM analysis.Brain imaging and behavior · 2025Pooled it
- The Abnormal Alternations of Brain Imaging in Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review.Journal of Alzheimer's disease reports · 2023Pooled it
- Resting-state functional MRI analysis of the brain's adaptation to chronic hypoxia: disease and environment.Quantitative imaging in medicine and surgery · 2026Article
- Brain pathology in relation to somatic diseases: Exploring the body-brain crosstalk.Journal of internal medicine · 2026Review
- Multidimensional cortical morphological alterations in COPD using explainable machine learning.iScience · 2026Article
- International evidence-based recommendations for point-of-care lung ultrasound : 2025 focused update of the 2012 recommendations.Intensive care medicine · 2026Article
- Neuropsychiatric disorders in pulmonary fibrosis: from brain network alterations to inflammatory mechanisms and therapeutic implications.Journal of neuroinflammation · 2026Review
- Functional reorganisation of lingual gyrus mediates cognitive impairment in COPD: a multimodal neuroimaging study.ERJ open research · 2026Article
- Pulmonary neuroendocrine cell-derived exosomes regulate iron homeostasis and oxidative stress in lung neurons.Science advances · 2026Article
- The lung-brain axis: elucidating the mechanisms of pulmonary-driven neurological disorders.Journal of neuroinflammation · 2026Review
- Unknotting the crosstalk between COPD and neuroinflammation.Journal of neuroinflammation · 2026Review
- Beyond the Pulmonary Functions: Altered Cognitive-Motor Performance and Motor Imagery in Children With Bronchiectasis.Pediatric pulmonology · 2026Article
- Bidirectional cortical gyrification alterations in chronic obstructive pulmonary disease: links to cognitive impairment and global initiative for chronic obstructive lung disease staging.BMC medical imaging · 2026Article
- Brain structural changes in COPD patients with cognitive impairment.Journal of neurology · 2026Review
- Associations among structural brain alterations, respiratory symptoms and cognitive impairment in patients with chronic obstructive pulmonary disease-related subclinical cognitive vulnerability: a multimodal neuroimaging study.Frontiers in aging neuroscience · 2026Article
- Observational
- Aberrant brain functional network in COPD patients with cognitive impairment: clinical manifestations, mechanisms and therapeutic strategies.Journal of neuroinflammation · 2025Review
- Observational
- Cognitive Impairment in Patients with Severe COPD: A Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Subjective Cognitive Decline in COPD - A Cross-Sectional Analysis of the Behavioral Risk Factor Surveillance System.Journal of general internal medicine · 2025Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundTo explore patterns of brain structural alteration in chronic obstructive pulmonary disease (COPD) patients with different levels of lung function impairment and the associations of those patterns with cognitive functional deficits using voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) analyses based on high-resolution structural MRI and diffusion tensor imaging (DTI).
methodsA total of 115 right-handed participants (26 severe, 29 moderate, and 29 mild COPD patients and a comparison group of 31 individuals without COPD) completed tests of cognitive (Montreal Cognitive Assessment [MoCA]) and pulmonary function (forced expiratory volume in 1 s [FEV1]) and underwent MRI scanning. VBM and TBSS analyses were used to identify changes in grey matter density (GMD) and white matter (WM) integrity in COPD patients. In addition, correlation analyses between these imaging parameter changes and cognitive and pulmonary functional impairments were performed.
resultsThere was no significant difference in brain structure between the comparison groups and the mild COPD patients. Patients with moderate COPD had atrophy of the left middle frontal gyrus and right opercular part/triangular part of the inferior frontal gyrus, and WM changes were present mainly in the superior and posterior corona radiata, corpus callosum and cingulum. Patients with severe COPD exhibited the most extensive changes in GMD and WM. Some grey matter (GM) and WM changes were correlated with MoCA scores and FEV1.
conclusionsThese findings suggest that patients with COPD exhibit progressive structural impairments in both the GM and the WM, along with impaired levels of lung function, highlighting the importance of early clinical interventions.
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Registered trials
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