SynthesisBMC infectious diseases2019
Long term surgical outcomes for infective endocarditis in people who inject drugs: a systematic review and meta-analysis.
Synthesis in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Therapeutic sensitivity to standard treatments in BRCA positive metastatic castration-resistant prostate cancer patients-a systematic review and meta-analysis.Prostate cancer and prostatic diseases · 2023Pooled it
- Longitudinal Outcomes of Mitral Valve Surgery for Infective Endocarditis Within a Repair-First Strategy.The Annals of thoracic surgery · 2026Article
- Article
- Characteristics of Infective Endocarditis in Intravenous Drug Users vs. Non-Users: A Retrospective Study Conducted in Bucharest, Romania.Medicina (Kaunas, Lithuania) · 2025Observational
- Bacterial and fungal infections in persons who inject drugs.Clinical microbiology reviews · 2025Review
- Percutaneous Mechanical Aspiration for Infective Endocarditis: Proceedings From an Inaugural Multidisciplinary Summit and Comprehensive Review.Journal of the Society for Cardiovascular Angiography & Interventions · 2024Review
- Article
- Mortality associated with bacterial and fungal infections and overdose among people with drug use diagnoses.Annals of epidemiology · 2023Article
- Characteristics and outcomes of angiovac-assisted debulking of intracardiac masses, thrombi, and endocarditis.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Article
- Grayken lessons: the role of an interdisciplinary endocarditis working group in evaluating and optimizing care for a woman with opioid use disorder requiring a second tricuspid valve replacement.Addiction science & clinical practice · 2023Article
- Characterization of patients receiving surgical versus non-surgical treatment for infective endocarditis in West Virginia.PloS one · 2023Article
- Five-Year Cardiovascular Outcomes after Infective Endocarditis in Patients with versus without Drug Use History.Journal of personalized medicine · 2022Article
- Correlates of 90-Day Mortality Among People Who Do and Do Not Inject Drugs With Infective Endocarditis in Seattle, Washington.Open forum infectious diseases · 2022Article
- Six Moments of Infection Prevention in Injection Drug Use: An Educational Toolkit for Clinicians.Open forum infectious diseases · 2022Article
- The opioid epidemic and endocarditis: Frontiers in the management of injection drug use-related endocarditis.JTCVS open · 2021Article
- A qualitative assessment of discharge against medical advice among patients hospitalized for injection-related bacterial infections in West Virginia.The International journal on drug policy · 2021Article
- Infective endocarditis in an intravenous drug user: multiple fatal complications.BMJ case reports · 2021Article
- Comparing right- and left sided injection-drug related infective endocarditis.Scientific reports · 2021Article
- Surgical treatment of infective endocarditis: Results in 831 patients from a single center.Journal of cardiac surgery · 2020Article
- Infective Endocarditis in Persons Who Use Drugs: Epidemiology, Current Management, and Emerging Treatments.Infectious disease clinics of North America · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundIn recent years, the number of infective endocarditis (IE) cases associated with injection drug use has increased. Clinical guidelines suggest deferring surgery for IE in people who inject drugs (PWID) due to a concern for worse outcomes in comparison to non-injectors (non-PWID). We performed a systematic review and meta-analysis of long-term outcomes in PWID who underwent cardiac surgery and compared these outcomes to non-PWID.
methodsWe systematically searched for studies reported between 1965 and 2018. We used an algorithm to estimate individual patient data (eIPD) from Kaplan-Meier (KM) curves and combined it with published individual patient data (IPD) to analyze long-term outcomes after cardiac surgery for IE in PWID. Our primary outcome was survival. Secondary outcomes were reoperation and mortality at 30-days, one-, five-, and 10-years. Random effects Cox regression was used for estimating survival.
resultsWe included 27 studies in the systematic review and 19 provided data (KM or IPD) for the meta-analysis. PWID were younger and more likely to have S. aureus than non-PWID. Survival at 30-days, one-, five-, and 10-years was 94.3, 81.0, 62.1, and 56.6% in PWID, respectively; and 96.4, 85.0, 70.3, and 63.4% in non-PWID. PWID had 47% greater hazard of death (HR 1.47, 95% CI, 1.05-2.05) and more than twice the hazard of reoperation (HR 2.37, 95% CI, 1.25-4.50) than non-PWID.
conclusionPWID had shorter survival that non-PWID. Implementing evidence-based interventions and testing new modalities are urgently needed to improve outcomes in PWID after cardiac surgery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.