Evidence map›Paper›PMID 31699052›Full record

Trial reportBMC anesthesiology2019

Transversus abdominis plane block with general anesthesia blunts the perioperative stress response in patients undergoing radical gastrectomy.

Ruizhu Liu, Haiyan Qin, Meng Wang, Kai Li, Guoqing Zhao

Registry-linked trialOpen access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05840406 (Effect of a Transversus Abdominis Plane Block on Operative Wound Healing, Stress, and Immune Response After a Cesarean Delivery), which is not on this map. Cited by 24 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 4 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05840406 nacompletednot on this mapstarted 2024, after this paper: background citation

Effect of a Transversus Abdominis Plane Block on Operative Wound Healing, Stress, and Immune Response After a Cesarean Delivery

TypeinterventionalSponsorUniversity Hospital Sestre MilosrdniceRan2024 to 2025Enrolled105ConditionsPostoperative Pain, Cesarean Section, Wound HealArmsPostoperative pain management with acetaminophen, Bilateral TAP Block with levobupivacaine, Bilateral TAP Block with levobupivacaine and dexmedetomidine, Postoperative pain management with tramadol, Postoperative pain management with ketoprofen
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ruizhu LiuDepartment of Anesthesiology, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Road, Changchun, 130000, Jilin Province, China.
Haiyan QinDepartment of Plastic Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130000, Jilin Province, China.
Meng WangDepartment of Cardiology, No. 965 Hospital of PLA, Jilin, 132000, Jilin Province, China.
Kai LiDepartment of Anesthesiology, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Road, Changchun, 130000, Jilin Province, China. likai82@126.com.
Guoqing ZhaoDepartment of Anesthesiology, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Road, Changchun, 130000, Jilin Province, China. zhaogq65@126.com.ORCID 0000-0002-9267-6301
Union Hospital · CNJilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSurgical stress induces the release of neuroendocrine mediators and cytokines during perioperative period, which may have adverse effects on cancer patients. While the surgical stress responsse can be affected by anesthetic technique. Therefore, we designed this study to assess whether subcostal transversus abdominis plane (TAP) block can affect perioperative neuroendocrine stress response, postoperative analgesia and postoperative recovery in patients undergoing radical gastrectomy under general anesthesia.

methodsSixty-five patients were recruited. Patients randomly received general anesthesia (control group), or general anesthesia combined with TAP block (40 mL of 0.375% ropivacaine) (TAP group). The primary outcome was neuroendocrine levels including norepinephrine (NE), epinephrine (E), cortisol (Cor), glucose (Glu), interleukin (IL)-6 and IL-10 during 48 h after surgery. Secondary outcomes included pain score, hemodynamic variables and recovery characteristics.

resultsData from 61 of 65 patients were analyzed. The levels of NE, E, Cor, and Glu were blunt by TAP block during perioperative period. The levels of IL-6 and IL-10 were significantly lower in TAP group than in control group. TAP block efficiently relieved postoperative acute pain up to 12 h postoperatively with more stable perioperative hemodynamics compared with control group.

conclusionsSubcostal TAP block blunts perioperative stress response and provides efficient analgesia, with good hemodynamic stability and minimal adverse effects.

Indexed as

Abdominal MusclesAgedAnesthesia, GeneralAnesthetics, LocalCytokinesFemaleGastrectomyHumansMaleMiddle AgedNerve BlockPerioperative PeriodPostoperative PainProspective StudiesRopivacaineStress, PhysiologicalAnesthetics, LocalCytokinesRopivacaineAnalgesiaGastric cancerNerve blockStress

Identifiers

PMID31699052
PMCPMC6839132
OpenAlexW2987846438

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.